Cargando…

Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation

The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3 (NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1, which in turn participates in the maturation of interleukin (IL)-1β and IL-18, which are mainly secreted via pyroptosis. Pyropt...

Descripción completa

Detalles Bibliográficos
Autores principales: Lucas-Ruiz, Fernando, Peñín-Franch, Alejandro, Pons, José Antonio, Ramírez, Pablo, Pelegrín, Pablo, Cuevas, Santiago, Baroja-Mazo, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698208/
https://www.ncbi.nlm.nih.gov/pubmed/36430874
http://dx.doi.org/10.3390/ijms232214396
_version_ 1784838759562346496
author Lucas-Ruiz, Fernando
Peñín-Franch, Alejandro
Pons, José Antonio
Ramírez, Pablo
Pelegrín, Pablo
Cuevas, Santiago
Baroja-Mazo, Alberto
author_facet Lucas-Ruiz, Fernando
Peñín-Franch, Alejandro
Pons, José Antonio
Ramírez, Pablo
Pelegrín, Pablo
Cuevas, Santiago
Baroja-Mazo, Alberto
author_sort Lucas-Ruiz, Fernando
collection PubMed
description The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3 (NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1, which in turn participates in the maturation of interleukin (IL)-1β and IL-18, which are mainly secreted via pyroptosis. Pyroptosis is a lytic type of cell death that is controlled by caspase-1 processing gasdermin D. The amino-terminal fragment of gasdermin D inserts into the plasma membrane, creating stable pores and enabling the release of several proinflammatory factors. The activation of NLRP3 inflammasome and pyroptosis has been involved in the progression of liver fibrosis and its end-stage cirrhosis, which is among the main etiologies for liver transplantation (LT). Moreover, the NLRP3 inflammasome is involved in ischemia–reperfusion injury and early inflammation and rejection after LT. In this review, we summarize the recent literature addressing the role of the NLRP3 inflammasome and pyroptosis in all stages involved in LT and argue the potential targeting of this pathway as a future therapeutic strategy to improve LT outcomes. Likewise, we also discuss the impact of graft quality influenced by donation after circulatory death and the expected role of machine perfusion technology to modify the injury response related to inflammasome activation.
format Online
Article
Text
id pubmed-9698208
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96982082022-11-26 Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation Lucas-Ruiz, Fernando Peñín-Franch, Alejandro Pons, José Antonio Ramírez, Pablo Pelegrín, Pablo Cuevas, Santiago Baroja-Mazo, Alberto Int J Mol Sci Review The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3 (NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1, which in turn participates in the maturation of interleukin (IL)-1β and IL-18, which are mainly secreted via pyroptosis. Pyroptosis is a lytic type of cell death that is controlled by caspase-1 processing gasdermin D. The amino-terminal fragment of gasdermin D inserts into the plasma membrane, creating stable pores and enabling the release of several proinflammatory factors. The activation of NLRP3 inflammasome and pyroptosis has been involved in the progression of liver fibrosis and its end-stage cirrhosis, which is among the main etiologies for liver transplantation (LT). Moreover, the NLRP3 inflammasome is involved in ischemia–reperfusion injury and early inflammation and rejection after LT. In this review, we summarize the recent literature addressing the role of the NLRP3 inflammasome and pyroptosis in all stages involved in LT and argue the potential targeting of this pathway as a future therapeutic strategy to improve LT outcomes. Likewise, we also discuss the impact of graft quality influenced by donation after circulatory death and the expected role of machine perfusion technology to modify the injury response related to inflammasome activation. MDPI 2022-11-19 /pmc/articles/PMC9698208/ /pubmed/36430874 http://dx.doi.org/10.3390/ijms232214396 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lucas-Ruiz, Fernando
Peñín-Franch, Alejandro
Pons, José Antonio
Ramírez, Pablo
Pelegrín, Pablo
Cuevas, Santiago
Baroja-Mazo, Alberto
Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation
title Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation
title_full Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation
title_fullStr Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation
title_full_unstemmed Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation
title_short Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation
title_sort emerging role of nlrp3 inflammasome and pyroptosis in liver transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698208/
https://www.ncbi.nlm.nih.gov/pubmed/36430874
http://dx.doi.org/10.3390/ijms232214396
work_keys_str_mv AT lucasruizfernando emergingroleofnlrp3inflammasomeandpyroptosisinlivertransplantation
AT peninfranchalejandro emergingroleofnlrp3inflammasomeandpyroptosisinlivertransplantation
AT ponsjoseantonio emergingroleofnlrp3inflammasomeandpyroptosisinlivertransplantation
AT ramirezpablo emergingroleofnlrp3inflammasomeandpyroptosisinlivertransplantation
AT pelegrinpablo emergingroleofnlrp3inflammasomeandpyroptosisinlivertransplantation
AT cuevassantiago emergingroleofnlrp3inflammasomeandpyroptosisinlivertransplantation
AT barojamazoalberto emergingroleofnlrp3inflammasomeandpyroptosisinlivertransplantation