Cargando…
Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study
Previous literature studies explored the association between brain neurometabolic changes detected by MR spectroscopy and symptoms in patients with tremor, as well as the outcome after deep brain stimulation (DBS) treatment. The purpose of our study was to evaluate the possible changes in cerebello-...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698245/ https://www.ncbi.nlm.nih.gov/pubmed/36362896 http://dx.doi.org/10.3390/life12111741 |
_version_ | 1784838768496214016 |
---|---|
author | Bruno, Federico Tommasino, Emanuele Catalucci, Alessia Piccin, Veronica Innocenzi, Antonio Carugno, Maria Ester Colarieti, Filippo Pertici, Leonardo Di Gioia, Antonio D’Alessandro, Claudia Fagotti, Cristina Sucapane, Patrizia Pistoia, Francesca Palumbo, Pierpaolo Arrigoni, Francesco Di Cesare, Ernesto Marini, Carmine Barile, Antonio Splendiani, Alessandra Masciocchi, Carlo |
author_facet | Bruno, Federico Tommasino, Emanuele Catalucci, Alessia Piccin, Veronica Innocenzi, Antonio Carugno, Maria Ester Colarieti, Filippo Pertici, Leonardo Di Gioia, Antonio D’Alessandro, Claudia Fagotti, Cristina Sucapane, Patrizia Pistoia, Francesca Palumbo, Pierpaolo Arrigoni, Francesco Di Cesare, Ernesto Marini, Carmine Barile, Antonio Splendiani, Alessandra Masciocchi, Carlo |
author_sort | Bruno, Federico |
collection | PubMed |
description | Previous literature studies explored the association between brain neurometabolic changes detected by MR spectroscopy and symptoms in patients with tremor, as well as the outcome after deep brain stimulation (DBS) treatment. The purpose of our study was to evaluate the possible changes in cerebello-thalamo-cortical neurometabolic findings using MR spectroscopy in patients submitted to MRgFUS thalamotomy. For this pilot study, we enrolled 10 ET patients eligible for MRgFUS thalamotomy. All patients were preoperatively submitted to 3T MR spectroscopy. Single-voxel MRS measurements were performed at the level of the thalamus contralateral to the treated side and the ipsilateral cerebellar dentate nucleus. Multivoxel acquisition was used for MRS at the level of the contralateral motor cortex. At the 6-month follow-up after treatment, we found a statistically significant increase in the Cho/Cr ratio at the level of the thalamus, a significant increase of the NAA/Cr ratio at the level of the dentate nucleus and a significant decrease of the NAA/Cho ratio at the level of the motor cortex. We found a significant positive correlation between cortical NAA/Cr and clinical improvement (i.e., tremor reduction) after treatment. A significant negative correlation was found between clinical improvement and thalamic and cerebellar NAA/Cr. Confirming some previous literature observations, our preliminary results revealed neurometabolic changes and suggest a possible prognostic role of the MRS assessment in patients with ET treated by MRgFUS. |
format | Online Article Text |
id | pubmed-9698245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96982452022-11-26 Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study Bruno, Federico Tommasino, Emanuele Catalucci, Alessia Piccin, Veronica Innocenzi, Antonio Carugno, Maria Ester Colarieti, Filippo Pertici, Leonardo Di Gioia, Antonio D’Alessandro, Claudia Fagotti, Cristina Sucapane, Patrizia Pistoia, Francesca Palumbo, Pierpaolo Arrigoni, Francesco Di Cesare, Ernesto Marini, Carmine Barile, Antonio Splendiani, Alessandra Masciocchi, Carlo Life (Basel) Article Previous literature studies explored the association between brain neurometabolic changes detected by MR spectroscopy and symptoms in patients with tremor, as well as the outcome after deep brain stimulation (DBS) treatment. The purpose of our study was to evaluate the possible changes in cerebello-thalamo-cortical neurometabolic findings using MR spectroscopy in patients submitted to MRgFUS thalamotomy. For this pilot study, we enrolled 10 ET patients eligible for MRgFUS thalamotomy. All patients were preoperatively submitted to 3T MR spectroscopy. Single-voxel MRS measurements were performed at the level of the thalamus contralateral to the treated side and the ipsilateral cerebellar dentate nucleus. Multivoxel acquisition was used for MRS at the level of the contralateral motor cortex. At the 6-month follow-up after treatment, we found a statistically significant increase in the Cho/Cr ratio at the level of the thalamus, a significant increase of the NAA/Cr ratio at the level of the dentate nucleus and a significant decrease of the NAA/Cho ratio at the level of the motor cortex. We found a significant positive correlation between cortical NAA/Cr and clinical improvement (i.e., tremor reduction) after treatment. A significant negative correlation was found between clinical improvement and thalamic and cerebellar NAA/Cr. Confirming some previous literature observations, our preliminary results revealed neurometabolic changes and suggest a possible prognostic role of the MRS assessment in patients with ET treated by MRgFUS. MDPI 2022-10-29 /pmc/articles/PMC9698245/ /pubmed/36362896 http://dx.doi.org/10.3390/life12111741 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bruno, Federico Tommasino, Emanuele Catalucci, Alessia Piccin, Veronica Innocenzi, Antonio Carugno, Maria Ester Colarieti, Filippo Pertici, Leonardo Di Gioia, Antonio D’Alessandro, Claudia Fagotti, Cristina Sucapane, Patrizia Pistoia, Francesca Palumbo, Pierpaolo Arrigoni, Francesco Di Cesare, Ernesto Marini, Carmine Barile, Antonio Splendiani, Alessandra Masciocchi, Carlo Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study |
title | Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study |
title_full | Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study |
title_fullStr | Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study |
title_full_unstemmed | Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study |
title_short | Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study |
title_sort | cerebello-thalamo-cortical mr spectroscopy in patients with essential tremor undergoing mrgfus thalamotomy: a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698245/ https://www.ncbi.nlm.nih.gov/pubmed/36362896 http://dx.doi.org/10.3390/life12111741 |
work_keys_str_mv | AT brunofederico cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT tommasinoemanuele cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT cataluccialessia cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT piccinveronica cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT innocenziantonio cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT carugnomariaester cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT colarietifilippo cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT perticileonardo cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT digioiaantonio cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT dalessandroclaudia cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT fagotticristina cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT sucapanepatrizia cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT pistoiafrancesca cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT palumbopierpaolo cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT arrigonifrancesco cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT dicesareernesto cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT marinicarmine cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT barileantonio cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT splendianialessandra cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy AT masciocchicarlo cerebellothalamocorticalmrspectroscopyinpatientswithessentialtremorundergoingmrgfusthalamotomyapilotstudy |