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No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial

Vitamin C is an important micronutrient for various immune cells. It increases phagocytic cell function and is necessary for T and natural killer (NK) cell development. Patients in need of an autologous hematopoietic stem cell transplantation (HSCT) are often vitamin C-depleted. We therefore hypothe...

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Autores principales: van Gorkom, Gwendolyn N. Y., Boerenkamp, Lara S., Gijsbers, Birgit L. M. G., van Ojik, Heidi H., Wodzig, Will K. W. H., Wieten, Lotte, Van Elssen, Catharina H. M. J., Bos, Gerard M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698268/
https://www.ncbi.nlm.nih.gov/pubmed/36432471
http://dx.doi.org/10.3390/nu14224784
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author van Gorkom, Gwendolyn N. Y.
Boerenkamp, Lara S.
Gijsbers, Birgit L. M. G.
van Ojik, Heidi H.
Wodzig, Will K. W. H.
Wieten, Lotte
Van Elssen, Catharina H. M. J.
Bos, Gerard M. J.
author_facet van Gorkom, Gwendolyn N. Y.
Boerenkamp, Lara S.
Gijsbers, Birgit L. M. G.
van Ojik, Heidi H.
Wodzig, Will K. W. H.
Wieten, Lotte
Van Elssen, Catharina H. M. J.
Bos, Gerard M. J.
author_sort van Gorkom, Gwendolyn N. Y.
collection PubMed
description Vitamin C is an important micronutrient for various immune cells. It increases phagocytic cell function and is necessary for T and natural killer (NK) cell development. Patients in need of an autologous hematopoietic stem cell transplantation (HSCT) are often vitamin C-depleted. We therefore hypothesized that vitamin C supplementation could improve immune recovery in autologous HSCT patients. This blinded, placebo-controlled trial included 44 patients randomized to receive vitamin C or a placebo. The following outcome measures used were clinical and immunological parameters, among others: time to neutrophil recovery, serum, and intracellular vitamin C values. Twenty-one patients received vitamin C, and 23 received a placebo. The time to neutrophil recovery did not differ between the two groups at 11.2 days (p = 0.96). There were no differences in hospitalization time (19.7 vs. 19.1 days, p = 0.80), the incidence of neutropenic fever (57% vs. 78%, p = 0.20), or 3-month overall survival (90.5% vs. 100%, p = 0.13). Bacteremia seemed to occur less in the vitamin C group (10% vs. 35%, p = 0.07). Our study shows no benefit from vitamin C supplementation on neutrophil recovery and hospitalization, despite possible lower rates of bacteremia in the vitamin C group. Therefore, we do not advise vitamin C supplementation in this treatment group.
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spelling pubmed-96982682022-11-26 No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial van Gorkom, Gwendolyn N. Y. Boerenkamp, Lara S. Gijsbers, Birgit L. M. G. van Ojik, Heidi H. Wodzig, Will K. W. H. Wieten, Lotte Van Elssen, Catharina H. M. J. Bos, Gerard M. J. Nutrients Article Vitamin C is an important micronutrient for various immune cells. It increases phagocytic cell function and is necessary for T and natural killer (NK) cell development. Patients in need of an autologous hematopoietic stem cell transplantation (HSCT) are often vitamin C-depleted. We therefore hypothesized that vitamin C supplementation could improve immune recovery in autologous HSCT patients. This blinded, placebo-controlled trial included 44 patients randomized to receive vitamin C or a placebo. The following outcome measures used were clinical and immunological parameters, among others: time to neutrophil recovery, serum, and intracellular vitamin C values. Twenty-one patients received vitamin C, and 23 received a placebo. The time to neutrophil recovery did not differ between the two groups at 11.2 days (p = 0.96). There were no differences in hospitalization time (19.7 vs. 19.1 days, p = 0.80), the incidence of neutropenic fever (57% vs. 78%, p = 0.20), or 3-month overall survival (90.5% vs. 100%, p = 0.13). Bacteremia seemed to occur less in the vitamin C group (10% vs. 35%, p = 0.07). Our study shows no benefit from vitamin C supplementation on neutrophil recovery and hospitalization, despite possible lower rates of bacteremia in the vitamin C group. Therefore, we do not advise vitamin C supplementation in this treatment group. MDPI 2022-11-11 /pmc/articles/PMC9698268/ /pubmed/36432471 http://dx.doi.org/10.3390/nu14224784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
van Gorkom, Gwendolyn N. Y.
Boerenkamp, Lara S.
Gijsbers, Birgit L. M. G.
van Ojik, Heidi H.
Wodzig, Will K. W. H.
Wieten, Lotte
Van Elssen, Catharina H. M. J.
Bos, Gerard M. J.
No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial
title No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial
title_full No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial
title_fullStr No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial
title_full_unstemmed No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial
title_short No Effect of Vitamin C Administration on Neutrophil Recovery in Autologous Stem Cell Transplantation for Myeloma or Lymphoma: A Blinded, Randomized Placebo-Controlled Trial
title_sort no effect of vitamin c administration on neutrophil recovery in autologous stem cell transplantation for myeloma or lymphoma: a blinded, randomized placebo-controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698268/
https://www.ncbi.nlm.nih.gov/pubmed/36432471
http://dx.doi.org/10.3390/nu14224784
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