Emerging Direct Targeting β-Catenin Agents

Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin drugs for clinical treatments have not been appro...

Descripción completa

Detalles Bibliográficos
Autores principales: Nalli, Marianna, Masci, Domiziana, Urbani, Andrea, La Regina, Giuseppe, Silvestri, Romano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698307/
https://www.ncbi.nlm.nih.gov/pubmed/36431838
http://dx.doi.org/10.3390/molecules27227735
_version_ 1784838783103926272
author Nalli, Marianna
Masci, Domiziana
Urbani, Andrea
La Regina, Giuseppe
Silvestri, Romano
author_facet Nalli, Marianna
Masci, Domiziana
Urbani, Andrea
La Regina, Giuseppe
Silvestri, Romano
author_sort Nalli, Marianna
collection PubMed
description Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin drugs for clinical treatments have not been approved so far. We focused on direct β-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule β-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of β-catenin agents.
format Online
Article
Text
id pubmed-9698307
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96983072022-11-26 Emerging Direct Targeting β-Catenin Agents Nalli, Marianna Masci, Domiziana Urbani, Andrea La Regina, Giuseppe Silvestri, Romano Molecules Review Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin drugs for clinical treatments have not been approved so far. We focused on direct β-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule β-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of β-catenin agents. MDPI 2022-11-10 /pmc/articles/PMC9698307/ /pubmed/36431838 http://dx.doi.org/10.3390/molecules27227735 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nalli, Marianna
Masci, Domiziana
Urbani, Andrea
La Regina, Giuseppe
Silvestri, Romano
Emerging Direct Targeting β-Catenin Agents
title Emerging Direct Targeting β-Catenin Agents
title_full Emerging Direct Targeting β-Catenin Agents
title_fullStr Emerging Direct Targeting β-Catenin Agents
title_full_unstemmed Emerging Direct Targeting β-Catenin Agents
title_short Emerging Direct Targeting β-Catenin Agents
title_sort emerging direct targeting β-catenin agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698307/
https://www.ncbi.nlm.nih.gov/pubmed/36431838
http://dx.doi.org/10.3390/molecules27227735
work_keys_str_mv AT nallimarianna emergingdirecttargetingbcateninagents
AT mascidomiziana emergingdirecttargetingbcateninagents
AT urbaniandrea emergingdirecttargetingbcateninagents
AT lareginagiuseppe emergingdirecttargetingbcateninagents
AT silvestriromano emergingdirecttargetingbcateninagents

Ejemplares similares