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Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers

Insulin resistance (IR) has been identified as a key factor in the appearance of non-alcoholic fatty liver disease (NAFLD) as it is related through a complex molecular biochemical and immunological mechanism. Our aim was to evaluate the relationship between different scales that estimate the risk of...

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Autores principales: Ramírez-Manent, José Ignacio, Martínez-Almoyna, Emilio, López, Carlos, Busquets-Cortés, Carla, González San Miguel, Hilda, López-González, Ángel Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698315/
https://www.ncbi.nlm.nih.gov/pubmed/36355176
http://dx.doi.org/10.3390/metabo12111093
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author Ramírez-Manent, José Ignacio
Martínez-Almoyna, Emilio
López, Carlos
Busquets-Cortés, Carla
González San Miguel, Hilda
López-González, Ángel Arturo
author_facet Ramírez-Manent, José Ignacio
Martínez-Almoyna, Emilio
López, Carlos
Busquets-Cortés, Carla
González San Miguel, Hilda
López-González, Ángel Arturo
author_sort Ramírez-Manent, José Ignacio
collection PubMed
description Insulin resistance (IR) has been identified as a key factor in the appearance of non-alcoholic fatty liver disease (NAFLD) as it is related through a complex molecular biochemical and immunological mechanism. Our aim was to evaluate the relationship between different scales that estimate the risk of IR and scales that determine the risk of NAFLD. This descriptive and cross-sectional study was performed in 219,477 Spanish workers from different sectors and Spanish regions. The prevalence of high values of all the IR scales increases as the values of the NAFLD and liver fibrosis scales increase. In the multivariate analysis, the risk of presenting high values in the IR scales increases greatly as the values of the NAFLD and hepatic fibrosis scales increase, with particularly high OR values when using the Metabolic Score for Insulin Resistance (METS-IR) scale (LAP high OR 42.20 (95% CI (39.10–45.56) and FLI high OR 32.35 (95% CI 31.10–33.61)). We can conclude that there is a direct relationship between the values of the IR scales and the NAFLD and liver fibrosis scales in our population.
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spelling pubmed-96983152022-11-26 Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers Ramírez-Manent, José Ignacio Martínez-Almoyna, Emilio López, Carlos Busquets-Cortés, Carla González San Miguel, Hilda López-González, Ángel Arturo Metabolites Article Insulin resistance (IR) has been identified as a key factor in the appearance of non-alcoholic fatty liver disease (NAFLD) as it is related through a complex molecular biochemical and immunological mechanism. Our aim was to evaluate the relationship between different scales that estimate the risk of IR and scales that determine the risk of NAFLD. This descriptive and cross-sectional study was performed in 219,477 Spanish workers from different sectors and Spanish regions. The prevalence of high values of all the IR scales increases as the values of the NAFLD and liver fibrosis scales increase. In the multivariate analysis, the risk of presenting high values in the IR scales increases greatly as the values of the NAFLD and hepatic fibrosis scales increase, with particularly high OR values when using the Metabolic Score for Insulin Resistance (METS-IR) scale (LAP high OR 42.20 (95% CI (39.10–45.56) and FLI high OR 32.35 (95% CI 31.10–33.61)). We can conclude that there is a direct relationship between the values of the IR scales and the NAFLD and liver fibrosis scales in our population. MDPI 2022-11-10 /pmc/articles/PMC9698315/ /pubmed/36355176 http://dx.doi.org/10.3390/metabo12111093 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ramírez-Manent, José Ignacio
Martínez-Almoyna, Emilio
López, Carlos
Busquets-Cortés, Carla
González San Miguel, Hilda
López-González, Ángel Arturo
Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers
title Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers
title_full Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers
title_fullStr Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers
title_full_unstemmed Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers
title_short Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers
title_sort relationship between insulin resistance risk scales and non-alcoholic fatty liver disease and liver fibrosis scales in 219,477 spanish workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698315/
https://www.ncbi.nlm.nih.gov/pubmed/36355176
http://dx.doi.org/10.3390/metabo12111093
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