BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

Conventional antidepressants are widely employed in several psychiatric and neurologic disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are only gradually being understood. This narrative review provides an up-to-date overview of the interplay between antidepres...

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Detalles Bibliográficos
Autores principales: Cubillos, Susana, Engmann, Olivia, Brancato, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698349/
https://www.ncbi.nlm.nih.gov/pubmed/36430921
http://dx.doi.org/10.3390/ijms232214445
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author Cubillos, Susana
Engmann, Olivia
Brancato, Anna
author_facet Cubillos, Susana
Engmann, Olivia
Brancato, Anna
author_sort Cubillos, Susana
collection PubMed
description Conventional antidepressants are widely employed in several psychiatric and neurologic disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are only gradually being understood. This narrative review provides an up-to-date overview of the interplay between antidepressant treatment and Brain-Derived Neurotrophic Factor (BDNF) signaling. In addition, the impact of nutritional, environmental and physiological factors on BDNF and the antidepressant response is outlined. This review underlines the necessity to include information on lifestyle choices in testing and developing antidepressant treatments in the future.
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spelling pubmed-96983492022-11-26 BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions Cubillos, Susana Engmann, Olivia Brancato, Anna Int J Mol Sci Review Conventional antidepressants are widely employed in several psychiatric and neurologic disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are only gradually being understood. This narrative review provides an up-to-date overview of the interplay between antidepressant treatment and Brain-Derived Neurotrophic Factor (BDNF) signaling. In addition, the impact of nutritional, environmental and physiological factors on BDNF and the antidepressant response is outlined. This review underlines the necessity to include information on lifestyle choices in testing and developing antidepressant treatments in the future. MDPI 2022-11-21 /pmc/articles/PMC9698349/ /pubmed/36430921 http://dx.doi.org/10.3390/ijms232214445 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cubillos, Susana
Engmann, Olivia
Brancato, Anna
BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions
title BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions
title_full BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions
title_fullStr BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions
title_full_unstemmed BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions
title_short BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions
title_sort bdnf as a mediator of antidepressant response: recent advances and lifestyle interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698349/
https://www.ncbi.nlm.nih.gov/pubmed/36430921
http://dx.doi.org/10.3390/ijms232214445
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