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The Role of Copper Homeostasis in Brain Disease
In the human body, copper is an important trace element and is a cofactor for several important enzymes involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, and neurotransmitter synthesis. Copper is also necessary for cellular processes, such as the r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698384/ https://www.ncbi.nlm.nih.gov/pubmed/36430330 http://dx.doi.org/10.3390/ijms232213850 |
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author | An, Yumei Li, Sunao Huang, Xinqi Chen, Xueshi Shan, Haiyan Zhang, Mingyang |
author_facet | An, Yumei Li, Sunao Huang, Xinqi Chen, Xueshi Shan, Haiyan Zhang, Mingyang |
author_sort | An, Yumei |
collection | PubMed |
description | In the human body, copper is an important trace element and is a cofactor for several important enzymes involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, and neurotransmitter synthesis. Copper is also necessary for cellular processes, such as the regulation of intracellular signal transduction, catecholamine balance, myelination of neurons, and efficient synaptic transmission in the central nervous system. Copper is naturally present in some foods and is available as a dietary supplement. Only small amounts of copper are typically stored in the body and a large amount of copper is excreted through bile and urine. Given the critical role of copper in a breadth of cellular processes, local concentrations of copper and the cellular distribution of copper transporter proteins in the brain are important to maintain the steady state of the internal environment. The dysfunction of copper metabolism or regulatory pathways results in an imbalance in copper homeostasis in the brain, which can lead to a myriad of acute and chronic pathological effects on neurological function. It suggests a unique mechanism linking copper homeostasis and neuronal activation within the central nervous system. This article explores the relationship between impaired copper homeostasis and neuropathophysiological progress in brain diseases. |
format | Online Article Text |
id | pubmed-9698384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96983842022-11-26 The Role of Copper Homeostasis in Brain Disease An, Yumei Li, Sunao Huang, Xinqi Chen, Xueshi Shan, Haiyan Zhang, Mingyang Int J Mol Sci Review In the human body, copper is an important trace element and is a cofactor for several important enzymes involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, and neurotransmitter synthesis. Copper is also necessary for cellular processes, such as the regulation of intracellular signal transduction, catecholamine balance, myelination of neurons, and efficient synaptic transmission in the central nervous system. Copper is naturally present in some foods and is available as a dietary supplement. Only small amounts of copper are typically stored in the body and a large amount of copper is excreted through bile and urine. Given the critical role of copper in a breadth of cellular processes, local concentrations of copper and the cellular distribution of copper transporter proteins in the brain are important to maintain the steady state of the internal environment. The dysfunction of copper metabolism or regulatory pathways results in an imbalance in copper homeostasis in the brain, which can lead to a myriad of acute and chronic pathological effects on neurological function. It suggests a unique mechanism linking copper homeostasis and neuronal activation within the central nervous system. This article explores the relationship between impaired copper homeostasis and neuropathophysiological progress in brain diseases. MDPI 2022-11-10 /pmc/articles/PMC9698384/ /pubmed/36430330 http://dx.doi.org/10.3390/ijms232213850 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review An, Yumei Li, Sunao Huang, Xinqi Chen, Xueshi Shan, Haiyan Zhang, Mingyang The Role of Copper Homeostasis in Brain Disease |
title | The Role of Copper Homeostasis in Brain Disease |
title_full | The Role of Copper Homeostasis in Brain Disease |
title_fullStr | The Role of Copper Homeostasis in Brain Disease |
title_full_unstemmed | The Role of Copper Homeostasis in Brain Disease |
title_short | The Role of Copper Homeostasis in Brain Disease |
title_sort | role of copper homeostasis in brain disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698384/ https://www.ncbi.nlm.nih.gov/pubmed/36430330 http://dx.doi.org/10.3390/ijms232213850 |
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