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Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study

At the onset of the SARS-CoV-2 pandemic, individual and social measures were strengthened through restrictive non-pharmaceutical interventions, labelled with the term “lockdown”. In Italy, there were two lockdowns (9 March 2020–3 May 2020 and 3 November 2020–27 March 2021). As part of preventive mea...

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Autores principales: Vetrugno, Giuseppe, Sanguinetti, Maurizio, Murri, Rita, Sali, Michela, Marchetti, Simona, Santangelo, Rosaria, Fantoni, Massimo, Cingolani, Antonella, Scoppettuolo, Giancarlo, Di Donato, Michele, Grassi, Vincenzo M., Foti, Federica, Marchese, Luca, De-Giorgio, Fabio, Oliva, Antonio, Staiti, Domenico, De Simone, Francesco Maria, Pascucci, Domenico, Cascini, Fidelia, Pastorino, Roberta, Pires Marafon, Denise, Cambieri, Andrea, Laurenti, Patrizia, Boccia, Stefania, Ricciardi, Walter, Franceschi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698425/
https://www.ncbi.nlm.nih.gov/pubmed/36366356
http://dx.doi.org/10.3390/vaccines10111847
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author Vetrugno, Giuseppe
Sanguinetti, Maurizio
Murri, Rita
Sali, Michela
Marchetti, Simona
Santangelo, Rosaria
Fantoni, Massimo
Cingolani, Antonella
Scoppettuolo, Giancarlo
Di Donato, Michele
Grassi, Vincenzo M.
Foti, Federica
Marchese, Luca
De-Giorgio, Fabio
Oliva, Antonio
Staiti, Domenico
De Simone, Francesco Maria
Pascucci, Domenico
Cascini, Fidelia
Pastorino, Roberta
Pires Marafon, Denise
Cambieri, Andrea
Laurenti, Patrizia
Boccia, Stefania
Ricciardi, Walter
Franceschi, Francesco
author_facet Vetrugno, Giuseppe
Sanguinetti, Maurizio
Murri, Rita
Sali, Michela
Marchetti, Simona
Santangelo, Rosaria
Fantoni, Massimo
Cingolani, Antonella
Scoppettuolo, Giancarlo
Di Donato, Michele
Grassi, Vincenzo M.
Foti, Federica
Marchese, Luca
De-Giorgio, Fabio
Oliva, Antonio
Staiti, Domenico
De Simone, Francesco Maria
Pascucci, Domenico
Cascini, Fidelia
Pastorino, Roberta
Pires Marafon, Denise
Cambieri, Andrea
Laurenti, Patrizia
Boccia, Stefania
Ricciardi, Walter
Franceschi, Francesco
author_sort Vetrugno, Giuseppe
collection PubMed
description At the onset of the SARS-CoV-2 pandemic, individual and social measures were strengthened through restrictive non-pharmaceutical interventions, labelled with the term “lockdown”. In Italy, there were two lockdowns (9 March 2020–3 May 2020 and 3 November 2020–27 March 2021). As part of preventive measures, healthcare workers and the administrative staff population of Policlinico A. Gemelli underwent nasopharyngeal swab tests from 1 March 2020 to 9 February 2022, a long time interval that includes the two aforementioned lockdowns. The population included 8958 people from 1 March 2020 to 31 December 2020; 8981 people from 1 January 2021 to 31 December 2021; and 8981 people from 1 January 2022 to 9 February 2022. We then analysed pseudo-anonymized data, using a retrospective observational approach to evaluate the impact of the lockdown on the incidence of SARS-CoV-2 infections within the population. Given the 14 day contagious period, the swab positivity rate (SPR) among the staff decreased significantly at the end of the first lockdown, every day prior to 18 May 2020, by 0.093 (p < 0.0001, CI = (−0.138–−0.047)). After the fourteenth day post the end of the first lockdown (18 May 2020), the SPR increased daily at a rate of 0.024 (p < 0.0001, 95% CI = (0.013–0.034)). In addition, the SPR appeared to increase significantly every day prior to 17 November 2020 by 0.024 (p < 0.0001, CI = (0.013–0.034)). After the fourteenth day post the start of the second lockdown (17 November 2020), the SPR decreased daily at a rate of 0.039 (p < 0.0001, 95% CI = (−0.050–−0.027)). These data demonstrate that, in our Institution, the lockdowns helped to both protect healthcare workers and maintain adequate standards of care for COVID and non-COVID patients for the duration of the state of emergency in Italy.
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spelling pubmed-96984252022-11-26 Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study Vetrugno, Giuseppe Sanguinetti, Maurizio Murri, Rita Sali, Michela Marchetti, Simona Santangelo, Rosaria Fantoni, Massimo Cingolani, Antonella Scoppettuolo, Giancarlo Di Donato, Michele Grassi, Vincenzo M. Foti, Federica Marchese, Luca De-Giorgio, Fabio Oliva, Antonio Staiti, Domenico De Simone, Francesco Maria Pascucci, Domenico Cascini, Fidelia Pastorino, Roberta Pires Marafon, Denise Cambieri, Andrea Laurenti, Patrizia Boccia, Stefania Ricciardi, Walter Franceschi, Francesco Vaccines (Basel) Article At the onset of the SARS-CoV-2 pandemic, individual and social measures were strengthened through restrictive non-pharmaceutical interventions, labelled with the term “lockdown”. In Italy, there were two lockdowns (9 March 2020–3 May 2020 and 3 November 2020–27 March 2021). As part of preventive measures, healthcare workers and the administrative staff population of Policlinico A. Gemelli underwent nasopharyngeal swab tests from 1 March 2020 to 9 February 2022, a long time interval that includes the two aforementioned lockdowns. The population included 8958 people from 1 March 2020 to 31 December 2020; 8981 people from 1 January 2021 to 31 December 2021; and 8981 people from 1 January 2022 to 9 February 2022. We then analysed pseudo-anonymized data, using a retrospective observational approach to evaluate the impact of the lockdown on the incidence of SARS-CoV-2 infections within the population. Given the 14 day contagious period, the swab positivity rate (SPR) among the staff decreased significantly at the end of the first lockdown, every day prior to 18 May 2020, by 0.093 (p < 0.0001, CI = (−0.138–−0.047)). After the fourteenth day post the end of the first lockdown (18 May 2020), the SPR increased daily at a rate of 0.024 (p < 0.0001, 95% CI = (0.013–0.034)). In addition, the SPR appeared to increase significantly every day prior to 17 November 2020 by 0.024 (p < 0.0001, CI = (0.013–0.034)). After the fourteenth day post the start of the second lockdown (17 November 2020), the SPR decreased daily at a rate of 0.039 (p < 0.0001, 95% CI = (−0.050–−0.027)). These data demonstrate that, in our Institution, the lockdowns helped to both protect healthcare workers and maintain adequate standards of care for COVID and non-COVID patients for the duration of the state of emergency in Italy. MDPI 2022-10-31 /pmc/articles/PMC9698425/ /pubmed/36366356 http://dx.doi.org/10.3390/vaccines10111847 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vetrugno, Giuseppe
Sanguinetti, Maurizio
Murri, Rita
Sali, Michela
Marchetti, Simona
Santangelo, Rosaria
Fantoni, Massimo
Cingolani, Antonella
Scoppettuolo, Giancarlo
Di Donato, Michele
Grassi, Vincenzo M.
Foti, Federica
Marchese, Luca
De-Giorgio, Fabio
Oliva, Antonio
Staiti, Domenico
De Simone, Francesco Maria
Pascucci, Domenico
Cascini, Fidelia
Pastorino, Roberta
Pires Marafon, Denise
Cambieri, Andrea
Laurenti, Patrizia
Boccia, Stefania
Ricciardi, Walter
Franceschi, Francesco
Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study
title Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study
title_full Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study
title_fullStr Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study
title_full_unstemmed Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study
title_short Effect of Lockdowns on Hospital Staff in a COVID Center: A Retrospective Observational Study
title_sort effect of lockdowns on hospital staff in a covid center: a retrospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698425/
https://www.ncbi.nlm.nih.gov/pubmed/36366356
http://dx.doi.org/10.3390/vaccines10111847
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