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Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy

Background: Coronavirus disease 2019 (COVID-19) vaccination hesitancy is a threat as COVID-19 vaccines have reduced both viral transmission and virus-associated mortality rates, particularly in high-risk subgroups. Solid organ transplant recipients (SOTRs) are particularly vulnerable, as the underly...

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Autores principales: Costantino, Andrea, Morlacchi, Letizia, Donato, Maria Francesca, Gramegna, Andrea, Farina, Elisa, Dibenedetto, Clara, Campise, Mariarosaria, Redaelli, Matteo, Perego, Marta, Alfieri, Carlo, Blasi, Francesco, Lampertico, Pietro, Favi, Evaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698445/
https://www.ncbi.nlm.nih.gov/pubmed/36366406
http://dx.doi.org/10.3390/vaccines10111899
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author Costantino, Andrea
Morlacchi, Letizia
Donato, Maria Francesca
Gramegna, Andrea
Farina, Elisa
Dibenedetto, Clara
Campise, Mariarosaria
Redaelli, Matteo
Perego, Marta
Alfieri, Carlo
Blasi, Francesco
Lampertico, Pietro
Favi, Evaldo
author_facet Costantino, Andrea
Morlacchi, Letizia
Donato, Maria Francesca
Gramegna, Andrea
Farina, Elisa
Dibenedetto, Clara
Campise, Mariarosaria
Redaelli, Matteo
Perego, Marta
Alfieri, Carlo
Blasi, Francesco
Lampertico, Pietro
Favi, Evaldo
author_sort Costantino, Andrea
collection PubMed
description Background: Coronavirus disease 2019 (COVID-19) vaccination hesitancy is a threat as COVID-19 vaccines have reduced both viral transmission and virus-associated mortality rates, particularly in high-risk subgroups. Solid organ transplant recipients (SOTRs) are particularly vulnerable, as the underlying causes of their organ failure and the chronic immunosuppression are associated with a lower immune response to COVID-19 vaccines, and with an excessive risk of death due to SARS-CoV-2 infection. We aimed to evaluate COVID-19 vaccination hesitancy and its reasons in a population of SOTRs. Methods: All the SOTRs attending our post-transplant clinics were asked to fill in a vaccination status form with specific validated questions related to their willingness to receive a third vaccine dose. In the case of negative answers, the patients were encouraged to explain the reasons for their refusal. Among the SOTRs (1899), 1019 were investigated (53.7%). Results: Overall, 5.01% (51/1019) of the SOTRs raised concerns regarding the future third dose vaccination. In more detail, hesitancy rates were 3.3% (15/453), 4.2% (7/166), and 7.3% (29/400) among the investigated liver, lung, and kidney transplant recipients, respectively (p = 0.0018). The main reasons for hesitancy were fear of adverse events (30/51, 58.8%) and perceived lack of efficacy (21/51, 41.2%). Conclusions: Full adherence to ongoing or future vaccination campaigns is crucial to prevent, or at least reduce, COVID-19-related morbidity and mortality in fragile patients. The identification of the reasons influencing COVID-19 vaccination hesitancy in these patients is very important to establish appropriate and targeted patient–doctor communication strategies, and to further implement specific vaccination campaigns.
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spelling pubmed-96984452022-11-26 Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy Costantino, Andrea Morlacchi, Letizia Donato, Maria Francesca Gramegna, Andrea Farina, Elisa Dibenedetto, Clara Campise, Mariarosaria Redaelli, Matteo Perego, Marta Alfieri, Carlo Blasi, Francesco Lampertico, Pietro Favi, Evaldo Vaccines (Basel) Communication Background: Coronavirus disease 2019 (COVID-19) vaccination hesitancy is a threat as COVID-19 vaccines have reduced both viral transmission and virus-associated mortality rates, particularly in high-risk subgroups. Solid organ transplant recipients (SOTRs) are particularly vulnerable, as the underlying causes of their organ failure and the chronic immunosuppression are associated with a lower immune response to COVID-19 vaccines, and with an excessive risk of death due to SARS-CoV-2 infection. We aimed to evaluate COVID-19 vaccination hesitancy and its reasons in a population of SOTRs. Methods: All the SOTRs attending our post-transplant clinics were asked to fill in a vaccination status form with specific validated questions related to their willingness to receive a third vaccine dose. In the case of negative answers, the patients were encouraged to explain the reasons for their refusal. Among the SOTRs (1899), 1019 were investigated (53.7%). Results: Overall, 5.01% (51/1019) of the SOTRs raised concerns regarding the future third dose vaccination. In more detail, hesitancy rates were 3.3% (15/453), 4.2% (7/166), and 7.3% (29/400) among the investigated liver, lung, and kidney transplant recipients, respectively (p = 0.0018). The main reasons for hesitancy were fear of adverse events (30/51, 58.8%) and perceived lack of efficacy (21/51, 41.2%). Conclusions: Full adherence to ongoing or future vaccination campaigns is crucial to prevent, or at least reduce, COVID-19-related morbidity and mortality in fragile patients. The identification of the reasons influencing COVID-19 vaccination hesitancy in these patients is very important to establish appropriate and targeted patient–doctor communication strategies, and to further implement specific vaccination campaigns. MDPI 2022-11-10 /pmc/articles/PMC9698445/ /pubmed/36366406 http://dx.doi.org/10.3390/vaccines10111899 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Costantino, Andrea
Morlacchi, Letizia
Donato, Maria Francesca
Gramegna, Andrea
Farina, Elisa
Dibenedetto, Clara
Campise, Mariarosaria
Redaelli, Matteo
Perego, Marta
Alfieri, Carlo
Blasi, Francesco
Lampertico, Pietro
Favi, Evaldo
Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy
title Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy
title_full Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy
title_fullStr Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy
title_full_unstemmed Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy
title_short Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy
title_sort hesitancy toward the full covid-19 vaccination among kidney, liver and lung transplant recipients in italy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698445/
https://www.ncbi.nlm.nih.gov/pubmed/36366406
http://dx.doi.org/10.3390/vaccines10111899
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