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Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
Glioblastoma (GBM) is the most malignant primary brain tumor. Despite increasing research on GBM treatment, the overall survival rate has not significantly improved over the last two decades. Although recent studies have focused on aberrant metabolism in GBM, there have been few advances in clinical...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698497/ https://www.ncbi.nlm.nih.gov/pubmed/36430293 http://dx.doi.org/10.3390/ijms232213818 |
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author | Lee, Haksoo Kim, Dahye Youn, BuHyun |
author_facet | Lee, Haksoo Kim, Dahye Youn, BuHyun |
author_sort | Lee, Haksoo |
collection | PubMed |
description | Glioblastoma (GBM) is the most malignant primary brain tumor. Despite increasing research on GBM treatment, the overall survival rate has not significantly improved over the last two decades. Although recent studies have focused on aberrant metabolism in GBM, there have been few advances in clinical application. Thus, it is important to understand the systemic metabolism to eradicate GBM. Together with the Warburg effect, lipid metabolism has emerged as necessary for GBM progression. GBM cells utilize lipid metabolism to acquire energy, membrane components, and signaling molecules for proliferation, survival, and response to the tumor microenvironment. In this review, we discuss fundamental cholesterol, fatty acid, and sphingolipid metabolism in the brain and the distinct metabolic alterations in GBM. In addition, we summarize various studies on the regulation of factors involved in lipid metabolism in GBM therapy. Focusing on the rewiring of lipid metabolism will be an alternative and effective therapeutic strategy for GBM treatment. |
format | Online Article Text |
id | pubmed-9698497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96984972022-11-26 Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment Lee, Haksoo Kim, Dahye Youn, BuHyun Int J Mol Sci Review Glioblastoma (GBM) is the most malignant primary brain tumor. Despite increasing research on GBM treatment, the overall survival rate has not significantly improved over the last two decades. Although recent studies have focused on aberrant metabolism in GBM, there have been few advances in clinical application. Thus, it is important to understand the systemic metabolism to eradicate GBM. Together with the Warburg effect, lipid metabolism has emerged as necessary for GBM progression. GBM cells utilize lipid metabolism to acquire energy, membrane components, and signaling molecules for proliferation, survival, and response to the tumor microenvironment. In this review, we discuss fundamental cholesterol, fatty acid, and sphingolipid metabolism in the brain and the distinct metabolic alterations in GBM. In addition, we summarize various studies on the regulation of factors involved in lipid metabolism in GBM therapy. Focusing on the rewiring of lipid metabolism will be an alternative and effective therapeutic strategy for GBM treatment. MDPI 2022-11-10 /pmc/articles/PMC9698497/ /pubmed/36430293 http://dx.doi.org/10.3390/ijms232213818 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Haksoo Kim, Dahye Youn, BuHyun Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment |
title | Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment |
title_full | Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment |
title_fullStr | Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment |
title_full_unstemmed | Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment |
title_short | Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment |
title_sort | targeting oncogenic rewiring of lipid metabolism for glioblastoma treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698497/ https://www.ncbi.nlm.nih.gov/pubmed/36430293 http://dx.doi.org/10.3390/ijms232213818 |
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