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Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment

Glioblastoma (GBM) is the most malignant primary brain tumor. Despite increasing research on GBM treatment, the overall survival rate has not significantly improved over the last two decades. Although recent studies have focused on aberrant metabolism in GBM, there have been few advances in clinical...

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Detalles Bibliográficos
Autores principales: Lee, Haksoo, Kim, Dahye, Youn, BuHyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698497/
https://www.ncbi.nlm.nih.gov/pubmed/36430293
http://dx.doi.org/10.3390/ijms232213818
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author Lee, Haksoo
Kim, Dahye
Youn, BuHyun
author_facet Lee, Haksoo
Kim, Dahye
Youn, BuHyun
author_sort Lee, Haksoo
collection PubMed
description Glioblastoma (GBM) is the most malignant primary brain tumor. Despite increasing research on GBM treatment, the overall survival rate has not significantly improved over the last two decades. Although recent studies have focused on aberrant metabolism in GBM, there have been few advances in clinical application. Thus, it is important to understand the systemic metabolism to eradicate GBM. Together with the Warburg effect, lipid metabolism has emerged as necessary for GBM progression. GBM cells utilize lipid metabolism to acquire energy, membrane components, and signaling molecules for proliferation, survival, and response to the tumor microenvironment. In this review, we discuss fundamental cholesterol, fatty acid, and sphingolipid metabolism in the brain and the distinct metabolic alterations in GBM. In addition, we summarize various studies on the regulation of factors involved in lipid metabolism in GBM therapy. Focusing on the rewiring of lipid metabolism will be an alternative and effective therapeutic strategy for GBM treatment.
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spelling pubmed-96984972022-11-26 Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment Lee, Haksoo Kim, Dahye Youn, BuHyun Int J Mol Sci Review Glioblastoma (GBM) is the most malignant primary brain tumor. Despite increasing research on GBM treatment, the overall survival rate has not significantly improved over the last two decades. Although recent studies have focused on aberrant metabolism in GBM, there have been few advances in clinical application. Thus, it is important to understand the systemic metabolism to eradicate GBM. Together with the Warburg effect, lipid metabolism has emerged as necessary for GBM progression. GBM cells utilize lipid metabolism to acquire energy, membrane components, and signaling molecules for proliferation, survival, and response to the tumor microenvironment. In this review, we discuss fundamental cholesterol, fatty acid, and sphingolipid metabolism in the brain and the distinct metabolic alterations in GBM. In addition, we summarize various studies on the regulation of factors involved in lipid metabolism in GBM therapy. Focusing on the rewiring of lipid metabolism will be an alternative and effective therapeutic strategy for GBM treatment. MDPI 2022-11-10 /pmc/articles/PMC9698497/ /pubmed/36430293 http://dx.doi.org/10.3390/ijms232213818 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Haksoo
Kim, Dahye
Youn, BuHyun
Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
title Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
title_full Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
title_fullStr Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
title_full_unstemmed Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
title_short Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment
title_sort targeting oncogenic rewiring of lipid metabolism for glioblastoma treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698497/
https://www.ncbi.nlm.nih.gov/pubmed/36430293
http://dx.doi.org/10.3390/ijms232213818
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