Cargando…

Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks

Aldehydes, particularly acetaldehyde, are carcinogenic molecules and their concentrations in foodstuffs should be controlled to avoid upper aerodigestive tract (UADT) and liver cancers. Highly reactive, acetaldehyde forms DNA and protein adducts, impairing physiological functions and leading to the...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreira, Mariana Toledo Gonçalves, Pereira, Patricia Ribeiro, Aquino, Adriano, Conte-Junior, Carlos Adam, Paschoalin, Vania Margaret Flosi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698545/
https://www.ncbi.nlm.nih.gov/pubmed/36430619
http://dx.doi.org/10.3390/ijms232214147
_version_ 1784838846037360640
author Moreira, Mariana Toledo Gonçalves
Pereira, Patricia Ribeiro
Aquino, Adriano
Conte-Junior, Carlos Adam
Paschoalin, Vania Margaret Flosi
author_facet Moreira, Mariana Toledo Gonçalves
Pereira, Patricia Ribeiro
Aquino, Adriano
Conte-Junior, Carlos Adam
Paschoalin, Vania Margaret Flosi
author_sort Moreira, Mariana Toledo Gonçalves
collection PubMed
description Aldehydes, particularly acetaldehyde, are carcinogenic molecules and their concentrations in foodstuffs should be controlled to avoid upper aerodigestive tract (UADT) and liver cancers. Highly reactive, acetaldehyde forms DNA and protein adducts, impairing physiological functions and leading to the development of pathological conditions. The consumption of aged beer, outside of the ethanol metabolism, exposes habitual drinkers to this carcinogen, whose concentrations can be over-increased due to post-brewing chemical and biochemical reactions. Storage-related changes are a challenge faced by the brewing industry, impacting volatile compound formation and triggering flavor instability. Aldehydes are among the volatile compounds formed during beer aging, recognized as off-flavor compounds. To track and understand aldehyde formation through multiple pathways during beer storage, consequent changes in flavor but particularly quality losses and harmful compound formation, this systematic review reunited data on volatile compound profiles through gas chromatography analyses from 2011 to 2021. Conditions to avoid flavor instability and successful methods for reducing beer staling, and consequent acetaldehyde accumulation, were raised by exploring the dynamic conversion between free and bound-state aldehydes. Future research should focus on implementing sensory analyses to investigate whether adding aldehyde-binding agents, e.g., cysteine and bisulfite, would contribute to consumer acceptance, restore beer flavor, and minimize acetaldehyde-related health damage.
format Online
Article
Text
id pubmed-9698545
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96985452022-11-26 Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks Moreira, Mariana Toledo Gonçalves Pereira, Patricia Ribeiro Aquino, Adriano Conte-Junior, Carlos Adam Paschoalin, Vania Margaret Flosi Int J Mol Sci Review Aldehydes, particularly acetaldehyde, are carcinogenic molecules and their concentrations in foodstuffs should be controlled to avoid upper aerodigestive tract (UADT) and liver cancers. Highly reactive, acetaldehyde forms DNA and protein adducts, impairing physiological functions and leading to the development of pathological conditions. The consumption of aged beer, outside of the ethanol metabolism, exposes habitual drinkers to this carcinogen, whose concentrations can be over-increased due to post-brewing chemical and biochemical reactions. Storage-related changes are a challenge faced by the brewing industry, impacting volatile compound formation and triggering flavor instability. Aldehydes are among the volatile compounds formed during beer aging, recognized as off-flavor compounds. To track and understand aldehyde formation through multiple pathways during beer storage, consequent changes in flavor but particularly quality losses and harmful compound formation, this systematic review reunited data on volatile compound profiles through gas chromatography analyses from 2011 to 2021. Conditions to avoid flavor instability and successful methods for reducing beer staling, and consequent acetaldehyde accumulation, were raised by exploring the dynamic conversion between free and bound-state aldehydes. Future research should focus on implementing sensory analyses to investigate whether adding aldehyde-binding agents, e.g., cysteine and bisulfite, would contribute to consumer acceptance, restore beer flavor, and minimize acetaldehyde-related health damage. MDPI 2022-11-16 /pmc/articles/PMC9698545/ /pubmed/36430619 http://dx.doi.org/10.3390/ijms232214147 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moreira, Mariana Toledo Gonçalves
Pereira, Patricia Ribeiro
Aquino, Adriano
Conte-Junior, Carlos Adam
Paschoalin, Vania Margaret Flosi
Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks
title Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks
title_full Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks
title_fullStr Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks
title_full_unstemmed Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks
title_short Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks
title_sort aldehyde accumulation in aged alcoholic beer: addressing acetaldehyde impacts on upper aerodigestive tract cancer risks
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698545/
https://www.ncbi.nlm.nih.gov/pubmed/36430619
http://dx.doi.org/10.3390/ijms232214147
work_keys_str_mv AT moreiramarianatoledogoncalves aldehydeaccumulationinagedalcoholicbeeraddressingacetaldehydeimpactsonupperaerodigestivetractcancerrisks
AT pereirapatriciaribeiro aldehydeaccumulationinagedalcoholicbeeraddressingacetaldehydeimpactsonupperaerodigestivetractcancerrisks
AT aquinoadriano aldehydeaccumulationinagedalcoholicbeeraddressingacetaldehydeimpactsonupperaerodigestivetractcancerrisks
AT contejuniorcarlosadam aldehydeaccumulationinagedalcoholicbeeraddressingacetaldehydeimpactsonupperaerodigestivetractcancerrisks
AT paschoalinvaniamargaretflosi aldehydeaccumulationinagedalcoholicbeeraddressingacetaldehydeimpactsonupperaerodigestivetractcancerrisks