Cargando…

The Importance of the Plasma Membrane in Atherogenesis

Atherosclerotic cardiovascular diseases are an important medical problem due to their high prevalence, impact on quality of life and prognosis. The pathogenesis of atherosclerosis is an urgent medical and social problem, the solution of which may improve the quality of diagnosis and treatment of pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Kotlyarov, Stanislav, Kotlyarova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698587/
https://www.ncbi.nlm.nih.gov/pubmed/36363591
http://dx.doi.org/10.3390/membranes12111036
_version_ 1784838857503539200
author Kotlyarov, Stanislav
Kotlyarova, Anna
author_facet Kotlyarov, Stanislav
Kotlyarova, Anna
author_sort Kotlyarov, Stanislav
collection PubMed
description Atherosclerotic cardiovascular diseases are an important medical problem due to their high prevalence, impact on quality of life and prognosis. The pathogenesis of atherosclerosis is an urgent medical and social problem, the solution of which may improve the quality of diagnosis and treatment of patients. Atherosclerosis is a complex chain of events, which proceeds over many years and in which many cells in the bloodstream and the vascular wall are involved. A growing body of evidence suggests that there are complex, closely linked molecular mechanisms that occur in the plasma membranes of cells involved in atherogenesis. Lipid transport, innate immune system receptor function, and hemodynamic regulation are linked to plasma membranes and their biophysical properties. A better understanding of these interrelationships will improve diagnostic quality and treatment efficacy.
format Online
Article
Text
id pubmed-9698587
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96985872022-11-26 The Importance of the Plasma Membrane in Atherogenesis Kotlyarov, Stanislav Kotlyarova, Anna Membranes (Basel) Review Atherosclerotic cardiovascular diseases are an important medical problem due to their high prevalence, impact on quality of life and prognosis. The pathogenesis of atherosclerosis is an urgent medical and social problem, the solution of which may improve the quality of diagnosis and treatment of patients. Atherosclerosis is a complex chain of events, which proceeds over many years and in which many cells in the bloodstream and the vascular wall are involved. A growing body of evidence suggests that there are complex, closely linked molecular mechanisms that occur in the plasma membranes of cells involved in atherogenesis. Lipid transport, innate immune system receptor function, and hemodynamic regulation are linked to plasma membranes and their biophysical properties. A better understanding of these interrelationships will improve diagnostic quality and treatment efficacy. MDPI 2022-10-24 /pmc/articles/PMC9698587/ /pubmed/36363591 http://dx.doi.org/10.3390/membranes12111036 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kotlyarov, Stanislav
Kotlyarova, Anna
The Importance of the Plasma Membrane in Atherogenesis
title The Importance of the Plasma Membrane in Atherogenesis
title_full The Importance of the Plasma Membrane in Atherogenesis
title_fullStr The Importance of the Plasma Membrane in Atherogenesis
title_full_unstemmed The Importance of the Plasma Membrane in Atherogenesis
title_short The Importance of the Plasma Membrane in Atherogenesis
title_sort importance of the plasma membrane in atherogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698587/
https://www.ncbi.nlm.nih.gov/pubmed/36363591
http://dx.doi.org/10.3390/membranes12111036
work_keys_str_mv AT kotlyarovstanislav theimportanceoftheplasmamembraneinatherogenesis
AT kotlyarovaanna theimportanceoftheplasmamembraneinatherogenesis
AT kotlyarovstanislav importanceoftheplasmamembraneinatherogenesis
AT kotlyarovaanna importanceoftheplasmamembraneinatherogenesis