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Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990–2019 Findings from Global Burden of Disease Study 2019

The aim of this study was to explore the most updated changing trends of non-rheumatic calcific aortic valve disease (nrCAVD) and reveal possible improvements. We analyzed the age-standardized rates (ASRs) of prevalence, incidence, disability-adjusted life-years (DALYs), and mortality trends of nrCA...

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Autores principales: Yang, Chengzhi, Xu, Haobo, Jia, Ruofei, Jin, Zening, Zhang, Changlin, Yuan, Jiansong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698619/
https://www.ncbi.nlm.nih.gov/pubmed/36431213
http://dx.doi.org/10.3390/jcm11226733
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author Yang, Chengzhi
Xu, Haobo
Jia, Ruofei
Jin, Zening
Zhang, Changlin
Yuan, Jiansong
author_facet Yang, Chengzhi
Xu, Haobo
Jia, Ruofei
Jin, Zening
Zhang, Changlin
Yuan, Jiansong
author_sort Yang, Chengzhi
collection PubMed
description The aim of this study was to explore the most updated changing trends of non-rheumatic calcific aortic valve disease (nrCAVD) and reveal possible improvements. We analyzed the age-standardized rates (ASRs) of prevalence, incidence, disability-adjusted life-years (DALYs), and mortality trends of nrCAVD from 1990 to 2019 using data from the Global Burden of Disease (GBD) study 2019. The relations between ASRs and socio-demographic index (SDI) were analyzed with Pearson’s correlation coefficients. Decomposition and frontier analysis were employed to reveal the contribution proportion of influence factors and regions where improvement can be achieved. In 2019, there were 9.40 million (95% uncertainty interval (UI): 8.07 to 10.89 million) individuals with nrCAVD globally. From 1990 to 2019, the prevalence rate of nrCAVD increased by 155.47% (95% IU: 141.66% to 171.7%), with the largest increase observed in the middle SDI region (821.11%, 95% UI: 709.87% to 944.23%). Globally, there were no significant changes in the mortality rate of nrCAVD (0.37%, 95% UI: −8.85% to 7.99%). The global DALYs decreased by 10.97% (95% UI: −17.94% to −3.46%). The population attributable fraction (PAF) of high systolic blood pressure increased in the population aged 15–49 years, while it declined slightly in population aged 50+ years. Population growth was the main contributing factor to the increased DALYs across the globe (74.73%), while aging was the driving force in the high-SDI region (80.27%). The Netherlands, Finland, Luxembourg, Germany, and Norway could reduce DALY rates of nrCAVD using their socio-demographic resources. According to these results, we revealed that the burden of nrCAVD increased markedly from 1990 to 2019 in high-SDI and high-middle-SDI regions. There was a downward trend in the mortality due to nrCAVD since 2013, which is possibly owing to profound advances in transcatheter aortic valve replacement. Some countries may reduce burdens of nrCAVD using their socio-demographic resources.
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spelling pubmed-96986192022-11-26 Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990–2019 Findings from Global Burden of Disease Study 2019 Yang, Chengzhi Xu, Haobo Jia, Ruofei Jin, Zening Zhang, Changlin Yuan, Jiansong J Clin Med Article The aim of this study was to explore the most updated changing trends of non-rheumatic calcific aortic valve disease (nrCAVD) and reveal possible improvements. We analyzed the age-standardized rates (ASRs) of prevalence, incidence, disability-adjusted life-years (DALYs), and mortality trends of nrCAVD from 1990 to 2019 using data from the Global Burden of Disease (GBD) study 2019. The relations between ASRs and socio-demographic index (SDI) were analyzed with Pearson’s correlation coefficients. Decomposition and frontier analysis were employed to reveal the contribution proportion of influence factors and regions where improvement can be achieved. In 2019, there were 9.40 million (95% uncertainty interval (UI): 8.07 to 10.89 million) individuals with nrCAVD globally. From 1990 to 2019, the prevalence rate of nrCAVD increased by 155.47% (95% IU: 141.66% to 171.7%), with the largest increase observed in the middle SDI region (821.11%, 95% UI: 709.87% to 944.23%). Globally, there were no significant changes in the mortality rate of nrCAVD (0.37%, 95% UI: −8.85% to 7.99%). The global DALYs decreased by 10.97% (95% UI: −17.94% to −3.46%). The population attributable fraction (PAF) of high systolic blood pressure increased in the population aged 15–49 years, while it declined slightly in population aged 50+ years. Population growth was the main contributing factor to the increased DALYs across the globe (74.73%), while aging was the driving force in the high-SDI region (80.27%). The Netherlands, Finland, Luxembourg, Germany, and Norway could reduce DALY rates of nrCAVD using their socio-demographic resources. According to these results, we revealed that the burden of nrCAVD increased markedly from 1990 to 2019 in high-SDI and high-middle-SDI regions. There was a downward trend in the mortality due to nrCAVD since 2013, which is possibly owing to profound advances in transcatheter aortic valve replacement. Some countries may reduce burdens of nrCAVD using their socio-demographic resources. MDPI 2022-11-14 /pmc/articles/PMC9698619/ /pubmed/36431213 http://dx.doi.org/10.3390/jcm11226733 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Chengzhi
Xu, Haobo
Jia, Ruofei
Jin, Zening
Zhang, Changlin
Yuan, Jiansong
Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990–2019 Findings from Global Burden of Disease Study 2019
title Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990–2019 Findings from Global Burden of Disease Study 2019
title_full Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990–2019 Findings from Global Burden of Disease Study 2019
title_fullStr Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990–2019 Findings from Global Burden of Disease Study 2019
title_full_unstemmed Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990–2019 Findings from Global Burden of Disease Study 2019
title_short Global Burden and Improvement Gap of Non-Rheumatic Calcific Aortic Valve Disease: 1990–2019 Findings from Global Burden of Disease Study 2019
title_sort global burden and improvement gap of non-rheumatic calcific aortic valve disease: 1990–2019 findings from global burden of disease study 2019
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698619/
https://www.ncbi.nlm.nih.gov/pubmed/36431213
http://dx.doi.org/10.3390/jcm11226733
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