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Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review
Uterine leiomyomas usually arise from the uterine body (95%), and rarely from the cervix (0.6%) or other urogenital sites. Lipoleiomyomas are benign, uncommon variants of leiomyomas (0.03–0.2%), histologically composed of smooth muscle cells and mature adipocytes; they usually occur in the uterine b...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698632/ https://www.ncbi.nlm.nih.gov/pubmed/36579603 http://dx.doi.org/10.3390/jpm12111852 |
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author | Palicelli, Andrea Ardighieri, Laura Broggi, Giuseppe Caltabiano, Rosario Melli, Beatrice Gelli, Maria Carolina Zanelli, Magda Bonasoni, Maria Paola Asaturova, Aleksandra Zizzo, Maurizio Aguzzoli, Lorenzo Baraldi, Ruggero Mandato, Vincenzo Dario |
author_facet | Palicelli, Andrea Ardighieri, Laura Broggi, Giuseppe Caltabiano, Rosario Melli, Beatrice Gelli, Maria Carolina Zanelli, Magda Bonasoni, Maria Paola Asaturova, Aleksandra Zizzo, Maurizio Aguzzoli, Lorenzo Baraldi, Ruggero Mandato, Vincenzo Dario |
author_sort | Palicelli, Andrea |
collection | PubMed |
description | Uterine leiomyomas usually arise from the uterine body (95%), and rarely from the cervix (0.6%) or other urogenital sites. Lipoleiomyomas are benign, uncommon variants of leiomyomas (0.03–0.2%), histologically composed of smooth muscle cells and mature adipocytes; they usually occur in the uterine body and exceptionally in the cervix. We performed the first systematic literature review of cervical lipoleiomyomas (PRISMA guidelines), presenting five new cases. Including our series, thirty-one detailed cases were reported in the literature (mainly in Asia). The age range was 35–74 years, revealing a higher mean age than conventional cervical leiomyomas (46.5 vs. 39.4 years). Patients were usually multiparous (94%), typically complaining of vaginal bleeding (11/31, 36%), pelvic/abdominal pain (10/31, 32%), and/or urinary disturbances (6/31, 19%) 1 week to 10 months before presentation. Clinical examination revealed a pedunculated tumor (48%), or prolapse of ≥1 pelvic organs (16%). Twenty-four (77%) patients underwent total hysterectomy ± additional surgery; simple myomectomy/excision was performed in five (16%) cases. Only one (3%) of our cases recurred 2 years after partial excision; no evidence of disease was found 13 years after recurrence excision. Adipocytes occupied ≤50% of the tumor volume. Hyaline or myxoid changes and cartilaginous metaplasia were uncommon histological findings. Surgically challenging cases or pregnant patients may require expert gynecologists. Interventional radiology or conservative treatments were rarely proposed. |
format | Online Article Text |
id | pubmed-9698632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96986322022-11-26 Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review Palicelli, Andrea Ardighieri, Laura Broggi, Giuseppe Caltabiano, Rosario Melli, Beatrice Gelli, Maria Carolina Zanelli, Magda Bonasoni, Maria Paola Asaturova, Aleksandra Zizzo, Maurizio Aguzzoli, Lorenzo Baraldi, Ruggero Mandato, Vincenzo Dario J Pers Med Article Uterine leiomyomas usually arise from the uterine body (95%), and rarely from the cervix (0.6%) or other urogenital sites. Lipoleiomyomas are benign, uncommon variants of leiomyomas (0.03–0.2%), histologically composed of smooth muscle cells and mature adipocytes; they usually occur in the uterine body and exceptionally in the cervix. We performed the first systematic literature review of cervical lipoleiomyomas (PRISMA guidelines), presenting five new cases. Including our series, thirty-one detailed cases were reported in the literature (mainly in Asia). The age range was 35–74 years, revealing a higher mean age than conventional cervical leiomyomas (46.5 vs. 39.4 years). Patients were usually multiparous (94%), typically complaining of vaginal bleeding (11/31, 36%), pelvic/abdominal pain (10/31, 32%), and/or urinary disturbances (6/31, 19%) 1 week to 10 months before presentation. Clinical examination revealed a pedunculated tumor (48%), or prolapse of ≥1 pelvic organs (16%). Twenty-four (77%) patients underwent total hysterectomy ± additional surgery; simple myomectomy/excision was performed in five (16%) cases. Only one (3%) of our cases recurred 2 years after partial excision; no evidence of disease was found 13 years after recurrence excision. Adipocytes occupied ≤50% of the tumor volume. Hyaline or myxoid changes and cartilaginous metaplasia were uncommon histological findings. Surgically challenging cases or pregnant patients may require expert gynecologists. Interventional radiology or conservative treatments were rarely proposed. MDPI 2022-11-06 /pmc/articles/PMC9698632/ /pubmed/36579603 http://dx.doi.org/10.3390/jpm12111852 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Palicelli, Andrea Ardighieri, Laura Broggi, Giuseppe Caltabiano, Rosario Melli, Beatrice Gelli, Maria Carolina Zanelli, Magda Bonasoni, Maria Paola Asaturova, Aleksandra Zizzo, Maurizio Aguzzoli, Lorenzo Baraldi, Ruggero Mandato, Vincenzo Dario Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review |
title | Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review |
title_full | Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review |
title_fullStr | Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review |
title_full_unstemmed | Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review |
title_short | Lipoleiomyomas of the Uterine Cervix: A New Series including the First Recurrent Case and the First Systematic Literature Review |
title_sort | lipoleiomyomas of the uterine cervix: a new series including the first recurrent case and the first systematic literature review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698632/ https://www.ncbi.nlm.nih.gov/pubmed/36579603 http://dx.doi.org/10.3390/jpm12111852 |
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