Cargando…

Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review

Recently, drug delivery systems based on nanoparticles for cancer treatment have become the centre of attention for researchers to design and fabricate drug carriers for anti-cancer drugs due to the lack of tumour-targeting activity in conventional pharmaceuticals. Poly(caprolactone)-b-poly(ethylene...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmad Shariff, Siti Hajar, Wan Abdul Khodir, Wan Khartini, Abd Hamid, Shafida, Haris, Muhammad Salahuddin, Ismail, Mohamad Wafiuddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698711/
https://www.ncbi.nlm.nih.gov/pubmed/36432974
http://dx.doi.org/10.3390/polym14224847
_version_ 1784838888285536256
author Ahmad Shariff, Siti Hajar
Wan Abdul Khodir, Wan Khartini
Abd Hamid, Shafida
Haris, Muhammad Salahuddin
Ismail, Mohamad Wafiuddin
author_facet Ahmad Shariff, Siti Hajar
Wan Abdul Khodir, Wan Khartini
Abd Hamid, Shafida
Haris, Muhammad Salahuddin
Ismail, Mohamad Wafiuddin
author_sort Ahmad Shariff, Siti Hajar
collection PubMed
description Recently, drug delivery systems based on nanoparticles for cancer treatment have become the centre of attention for researchers to design and fabricate drug carriers for anti-cancer drugs due to the lack of tumour-targeting activity in conventional pharmaceuticals. Poly(caprolactone)-b-poly(ethylene glycol) (PCL-PEG)-based micelles have attracted significant attention as a potential drug carrier intended for human use. Since their first discovery, the Food and Drug Administration (FDA)-approved polymers have been studied extensively for various biomedical applications, specifically cancer therapy. The application of PCL-PEG micelles in different cancer therapies has been recorded in countless research studies for their efficacy as drug cargos. However, systematic studies on the effectiveness of PCL-PEG micelles of specific cancers for pharmaceutical applications are still lacking. As breast cancer is reported as the most prevalent cancer worldwide, we aim to systematically review all available literature that has published research findings on the PCL-PEG-based micelles as drug cargo for therapy. We further discussed the preparation method and the anti-tumour efficacy of the micelles. Using a prearranged search string, Scopus and Science Direct were selected as the databases for the systematic searching strategy. Only eight of the 314 articles met the inclusion requirements and were used for data synthesis. From the review, all studies reported the efficiency of PCL-PEG-based micelles, which act as drug cargo for breast cancer therapy.
format Online
Article
Text
id pubmed-9698711
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96987112022-11-26 Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review Ahmad Shariff, Siti Hajar Wan Abdul Khodir, Wan Khartini Abd Hamid, Shafida Haris, Muhammad Salahuddin Ismail, Mohamad Wafiuddin Polymers (Basel) Review Recently, drug delivery systems based on nanoparticles for cancer treatment have become the centre of attention for researchers to design and fabricate drug carriers for anti-cancer drugs due to the lack of tumour-targeting activity in conventional pharmaceuticals. Poly(caprolactone)-b-poly(ethylene glycol) (PCL-PEG)-based micelles have attracted significant attention as a potential drug carrier intended for human use. Since their first discovery, the Food and Drug Administration (FDA)-approved polymers have been studied extensively for various biomedical applications, specifically cancer therapy. The application of PCL-PEG micelles in different cancer therapies has been recorded in countless research studies for their efficacy as drug cargos. However, systematic studies on the effectiveness of PCL-PEG micelles of specific cancers for pharmaceutical applications are still lacking. As breast cancer is reported as the most prevalent cancer worldwide, we aim to systematically review all available literature that has published research findings on the PCL-PEG-based micelles as drug cargo for therapy. We further discussed the preparation method and the anti-tumour efficacy of the micelles. Using a prearranged search string, Scopus and Science Direct were selected as the databases for the systematic searching strategy. Only eight of the 314 articles met the inclusion requirements and were used for data synthesis. From the review, all studies reported the efficiency of PCL-PEG-based micelles, which act as drug cargo for breast cancer therapy. MDPI 2022-11-10 /pmc/articles/PMC9698711/ /pubmed/36432974 http://dx.doi.org/10.3390/polym14224847 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ahmad Shariff, Siti Hajar
Wan Abdul Khodir, Wan Khartini
Abd Hamid, Shafida
Haris, Muhammad Salahuddin
Ismail, Mohamad Wafiuddin
Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review
title Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review
title_full Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review
title_fullStr Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review
title_full_unstemmed Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review
title_short Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review
title_sort poly(caprolactone)-b-poly(ethylene glycol)-based polymeric micelles as drug carriers for efficient breast cancer therapy: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698711/
https://www.ncbi.nlm.nih.gov/pubmed/36432974
http://dx.doi.org/10.3390/polym14224847
work_keys_str_mv AT ahmadshariffsitihajar polycaprolactonebpolyethyleneglycolbasedpolymericmicellesasdrugcarriersforefficientbreastcancertherapyasystematicreview
AT wanabdulkhodirwankhartini polycaprolactonebpolyethyleneglycolbasedpolymericmicellesasdrugcarriersforefficientbreastcancertherapyasystematicreview
AT abdhamidshafida polycaprolactonebpolyethyleneglycolbasedpolymericmicellesasdrugcarriersforefficientbreastcancertherapyasystematicreview
AT harismuhammadsalahuddin polycaprolactonebpolyethyleneglycolbasedpolymericmicellesasdrugcarriersforefficientbreastcancertherapyasystematicreview
AT ismailmohamadwafiuddin polycaprolactonebpolyethyleneglycolbasedpolymericmicellesasdrugcarriersforefficientbreastcancertherapyasystematicreview