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From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR signaling pathway is aberrantly activated because of oncogenic driver alterations and further enhanced by chemotherapy as a mechanism of dru...

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Detalles Bibliográficos
Autores principales:	Astolfi, Andrea, Milano, Francesca, Palazzotti, Deborah, Brea, Jose, Pismataro, Maria Chiara, Morlando, Mariangela, Tabarrini, Oriana, Loza, Maria Isabel, Massari, Serena, Martelli, Maria Paola, Barreca, Maria Letizia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698716/ https://www.ncbi.nlm.nih.gov/pubmed/36365115 http://dx.doi.org/10.3390/pharmaceutics14112295

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