The SYNGAP1 3′UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK

Fused in sarcoma (FUS) is a pathogenic RNA-binding protein in amyotrophic lateral sclerosis (ALS). We previously reported that FUS stabilizes Synaptic Ras-GTPase activating protein 1 (Syngap1) mRNA at its 3′ untranslated region (UTR) and maintains spine maturation. To elucidate the pathologic roles...

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Detalles Bibliográficos
Autores principales: Yokoi, Satoshi, Ito, Takuji, Sahashi, Kentaro, Nakatochi, Masahiro, Nakamura, Ryoichi, Tohnai, Genki, Fujioka, Yusuke, Ishigaki, Shinsuke, Udagawa, Tsuyoshi, Izumi, Yuishin, Morita, Mitsuya, Kano, Osamu, Oda, Masaya, Sone, Takefumi, Okano, Hideyuki, Atsuta, Naoki, Katsuno, Masahisa, Okada, Yohei, Sobue, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698725/
https://www.ncbi.nlm.nih.gov/pubmed/36261283
http://dx.doi.org/10.1523/JNEUROSCI.0455-22.2022

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