Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population

As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results s...

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Autores principales: Quach, Huy Quang, Ovsyannikova, Inna G., Grill, Diane E., Warner, Nathaniel D., Poland, Gregory A., Kennedy, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698789/
https://www.ncbi.nlm.nih.gov/pubmed/36366367
http://dx.doi.org/10.3390/vaccines10111859
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author Quach, Huy Quang
Ovsyannikova, Inna G.
Grill, Diane E.
Warner, Nathaniel D.
Poland, Gregory A.
Kennedy, Richard B.
author_facet Quach, Huy Quang
Ovsyannikova, Inna G.
Grill, Diane E.
Warner, Nathaniel D.
Poland, Gregory A.
Kennedy, Richard B.
author_sort Quach, Huy Quang
collection PubMed
description As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.
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spelling pubmed-96987892022-11-26 Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population Quach, Huy Quang Ovsyannikova, Inna G. Grill, Diane E. Warner, Nathaniel D. Poland, Gregory A. Kennedy, Richard B. Vaccines (Basel) Brief Report As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks. MDPI 2022-11-03 /pmc/articles/PMC9698789/ /pubmed/36366367 http://dx.doi.org/10.3390/vaccines10111859 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Quach, Huy Quang
Ovsyannikova, Inna G.
Grill, Diane E.
Warner, Nathaniel D.
Poland, Gregory A.
Kennedy, Richard B.
Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population
title Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population
title_full Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population
title_fullStr Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population
title_full_unstemmed Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population
title_short Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population
title_sort seroprevalence of measles antibodies in a highly mmr-vaccinated population
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698789/
https://www.ncbi.nlm.nih.gov/pubmed/36366367
http://dx.doi.org/10.3390/vaccines10111859
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