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First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758

Contrary to humans, candidiasis is a rare infection in animals. However, in reptiles, candidiasis can cause gastrointestinal, cutaneous, or rarely systemic infections in stressed animals. The infections due to Yarrowia lipolytica have been increasingly described in human medicine, and hundreds of ca...

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Autores principales: Iurescia, Manuela, Santini, Andrea, Montagnani, Marco, Diaconu, Elena Lavinia, Stravino, Fiorentino, Agnelli, Devid, Vergari, Emanuela, Fichi, Gianluca, Eleni, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698808/
https://www.ncbi.nlm.nih.gov/pubmed/36365006
http://dx.doi.org/10.3390/pathogens11111255
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author Iurescia, Manuela
Santini, Andrea
Montagnani, Marco
Diaconu, Elena Lavinia
Stravino, Fiorentino
Agnelli, Devid
Vergari, Emanuela
Fichi, Gianluca
Eleni, Claudia
author_facet Iurescia, Manuela
Santini, Andrea
Montagnani, Marco
Diaconu, Elena Lavinia
Stravino, Fiorentino
Agnelli, Devid
Vergari, Emanuela
Fichi, Gianluca
Eleni, Claudia
author_sort Iurescia, Manuela
collection PubMed
description Contrary to humans, candidiasis is a rare infection in animals. However, in reptiles, candidiasis can cause gastrointestinal, cutaneous, or rarely systemic infections in stressed animals. The infections due to Yarrowia lipolytica have been increasingly described in human medicine, and hundreds of cases are reported, comprised of granulomatous lung lesions. Herein, granulomatous pneumonia of a spectacled caiman, Caiman crocodilus, was described, and the presence of Y. lipolytica in the lesion was confirmed through histopathology, microbiologic cultures, and molecular methods. The cause of death of the spectacled caiman was ascribed to bacterial shock septicemia consequentially to a traumatic lesion. However, in the right lung, several nodules containing white exudate were evidenced. At mycological and molecular analyses, Y. lipolytica was evidenced, and the histological finding confirmed the presence of a Candida infection in the lung granulomatous lesions. The comparison of ITS sequences with 11 Yarrowia spp. isolates, recently described in green sea turtles, and with a human strain was conducted, and the whole genome of a strain isolated in the spectacled caiman was sequenced. Even though Y. lipolytica is considered a non-pathogenic yeast and has been rarely described in animals, it seems to cause granulomatous lesions in reptiles as in humans.
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spelling pubmed-96988082022-11-26 First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758 Iurescia, Manuela Santini, Andrea Montagnani, Marco Diaconu, Elena Lavinia Stravino, Fiorentino Agnelli, Devid Vergari, Emanuela Fichi, Gianluca Eleni, Claudia Pathogens Article Contrary to humans, candidiasis is a rare infection in animals. However, in reptiles, candidiasis can cause gastrointestinal, cutaneous, or rarely systemic infections in stressed animals. The infections due to Yarrowia lipolytica have been increasingly described in human medicine, and hundreds of cases are reported, comprised of granulomatous lung lesions. Herein, granulomatous pneumonia of a spectacled caiman, Caiman crocodilus, was described, and the presence of Y. lipolytica in the lesion was confirmed through histopathology, microbiologic cultures, and molecular methods. The cause of death of the spectacled caiman was ascribed to bacterial shock septicemia consequentially to a traumatic lesion. However, in the right lung, several nodules containing white exudate were evidenced. At mycological and molecular analyses, Y. lipolytica was evidenced, and the histological finding confirmed the presence of a Candida infection in the lung granulomatous lesions. The comparison of ITS sequences with 11 Yarrowia spp. isolates, recently described in green sea turtles, and with a human strain was conducted, and the whole genome of a strain isolated in the spectacled caiman was sequenced. Even though Y. lipolytica is considered a non-pathogenic yeast and has been rarely described in animals, it seems to cause granulomatous lesions in reptiles as in humans. MDPI 2022-10-28 /pmc/articles/PMC9698808/ /pubmed/36365006 http://dx.doi.org/10.3390/pathogens11111255 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iurescia, Manuela
Santini, Andrea
Montagnani, Marco
Diaconu, Elena Lavinia
Stravino, Fiorentino
Agnelli, Devid
Vergari, Emanuela
Fichi, Gianluca
Eleni, Claudia
First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758
title First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758
title_full First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758
title_fullStr First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758
title_full_unstemmed First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758
title_short First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758
title_sort first isolation of yarrowia lipolytica in a granulomatous pneumonia of a spectacled caiman, caiman crocodilus linnaeus, 1758
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698808/
https://www.ncbi.nlm.nih.gov/pubmed/36365006
http://dx.doi.org/10.3390/pathogens11111255
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