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Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes

COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as “long-COVID” or “post-COVID-19” syndrome. Despite an increasing body of literature, long COVID remains poorly characterized. We retrospectively analysed data from electronic medical records of patients adm...

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Autores principales: Spinicci, Michele, Graziani, Lucia, Tilli, Marta, Nkurunziza, Jerusalem, Vellere, Iacopo, Borchi, Beatrice, Mencarini, Jessica, Campolmi, Irene, Gori, Leonardo, Giovannoni, Lorenzo, Amato, Carla, Livi, Luca, Rasero, Laura, Fattirolli, Francesco, Marcucci, Rossella, Giusti, Betti, Olivotto, Iacopo, Tomassetti, Sara, Lavorini, Federico, Maggi, Laura, Annunziato, Francesco, Marchionni, Niccolò, Zammarchi, Lorenzo, Bartoloni, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698829/
https://www.ncbi.nlm.nih.gov/pubmed/36366465
http://dx.doi.org/10.3390/v14112367
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author Spinicci, Michele
Graziani, Lucia
Tilli, Marta
Nkurunziza, Jerusalem
Vellere, Iacopo
Borchi, Beatrice
Mencarini, Jessica
Campolmi, Irene
Gori, Leonardo
Giovannoni, Lorenzo
Amato, Carla
Livi, Luca
Rasero, Laura
Fattirolli, Francesco
Marcucci, Rossella
Giusti, Betti
Olivotto, Iacopo
Tomassetti, Sara
Lavorini, Federico
Maggi, Laura
Annunziato, Francesco
Marchionni, Niccolò
Zammarchi, Lorenzo
Bartoloni, Alessandro
author_facet Spinicci, Michele
Graziani, Lucia
Tilli, Marta
Nkurunziza, Jerusalem
Vellere, Iacopo
Borchi, Beatrice
Mencarini, Jessica
Campolmi, Irene
Gori, Leonardo
Giovannoni, Lorenzo
Amato, Carla
Livi, Luca
Rasero, Laura
Fattirolli, Francesco
Marcucci, Rossella
Giusti, Betti
Olivotto, Iacopo
Tomassetti, Sara
Lavorini, Federico
Maggi, Laura
Annunziato, Francesco
Marchionni, Niccolò
Zammarchi, Lorenzo
Bartoloni, Alessandro
author_sort Spinicci, Michele
collection PubMed
description COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as “long-COVID” or “post-COVID-19” syndrome. Despite an increasing body of literature, long COVID remains poorly characterized. We retrospectively analysed data from electronic medical records of patients admitted to the post-COVID-19 outpatient service of the Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy, between June 2020 and June 2021, 4–12 weeks after hospital discharge. A total of 428 patients, 41% women, median age 64 years, underwent a follow-up visit a median 53 days after hospital discharge. Overall, 76% patients reported at least one persistent symptom, including dyspnoea (37%), chronic fatigue (36%), insomnia (16%), visual disorders (13%) and brain fog (13%). Increasing oxygen support (OR 1.4, 95% CI 1.1–1.8), use of immunosuppressants (OR 6.4, 95% CI 1.5–28) and female sex (OR 1.8, 95% CI 1.1–2.9) were associated with a higher risk of long COVID symptoms. Comparison between symptomatic patients infected in the period March–December 2020 (prevalent circulation of wild-type SARS-CoV-2) with those infected in the period January–April 2021 (prevalent circulation of B.1.1.7 Alpha variant) showed a significant modification in the pattern of symptoms belonging to the neurological and cognitive/emotional categories. Our findings confirmed shortness of breath and chronic fatigue as the most frequent long COVID manifestations, while female sex and severe COVID-19 course were the main risk factors for developing lingering symptoms. SARS-CoV-2 variants may induce different long COVID phenotypes, possibly due to changes in cell tropism and differences in viral–host interaction.
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spelling pubmed-96988292022-11-26 Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes Spinicci, Michele Graziani, Lucia Tilli, Marta Nkurunziza, Jerusalem Vellere, Iacopo Borchi, Beatrice Mencarini, Jessica Campolmi, Irene Gori, Leonardo Giovannoni, Lorenzo Amato, Carla Livi, Luca Rasero, Laura Fattirolli, Francesco Marcucci, Rossella Giusti, Betti Olivotto, Iacopo Tomassetti, Sara Lavorini, Federico Maggi, Laura Annunziato, Francesco Marchionni, Niccolò Zammarchi, Lorenzo Bartoloni, Alessandro Viruses Article COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as “long-COVID” or “post-COVID-19” syndrome. Despite an increasing body of literature, long COVID remains poorly characterized. We retrospectively analysed data from electronic medical records of patients admitted to the post-COVID-19 outpatient service of the Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy, between June 2020 and June 2021, 4–12 weeks after hospital discharge. A total of 428 patients, 41% women, median age 64 years, underwent a follow-up visit a median 53 days after hospital discharge. Overall, 76% patients reported at least one persistent symptom, including dyspnoea (37%), chronic fatigue (36%), insomnia (16%), visual disorders (13%) and brain fog (13%). Increasing oxygen support (OR 1.4, 95% CI 1.1–1.8), use of immunosuppressants (OR 6.4, 95% CI 1.5–28) and female sex (OR 1.8, 95% CI 1.1–2.9) were associated with a higher risk of long COVID symptoms. Comparison between symptomatic patients infected in the period March–December 2020 (prevalent circulation of wild-type SARS-CoV-2) with those infected in the period January–April 2021 (prevalent circulation of B.1.1.7 Alpha variant) showed a significant modification in the pattern of symptoms belonging to the neurological and cognitive/emotional categories. Our findings confirmed shortness of breath and chronic fatigue as the most frequent long COVID manifestations, while female sex and severe COVID-19 course were the main risk factors for developing lingering symptoms. SARS-CoV-2 variants may induce different long COVID phenotypes, possibly due to changes in cell tropism and differences in viral–host interaction. MDPI 2022-10-27 /pmc/articles/PMC9698829/ /pubmed/36366465 http://dx.doi.org/10.3390/v14112367 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spinicci, Michele
Graziani, Lucia
Tilli, Marta
Nkurunziza, Jerusalem
Vellere, Iacopo
Borchi, Beatrice
Mencarini, Jessica
Campolmi, Irene
Gori, Leonardo
Giovannoni, Lorenzo
Amato, Carla
Livi, Luca
Rasero, Laura
Fattirolli, Francesco
Marcucci, Rossella
Giusti, Betti
Olivotto, Iacopo
Tomassetti, Sara
Lavorini, Federico
Maggi, Laura
Annunziato, Francesco
Marchionni, Niccolò
Zammarchi, Lorenzo
Bartoloni, Alessandro
Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes
title Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes
title_full Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes
title_fullStr Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes
title_full_unstemmed Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes
title_short Infection with SARS-CoV-2 Variants Is Associated with Different Long COVID Phenotypes
title_sort infection with sars-cov-2 variants is associated with different long covid phenotypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698829/
https://www.ncbi.nlm.nih.gov/pubmed/36366465
http://dx.doi.org/10.3390/v14112367
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