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Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry

There is a large heterogeneity among patients presenting with cardiogenic shock (CS). It is crucial to better apprehend this heterogeneity in order to adapt treatments and improve prognoses in these severe patients. Notably, the presence (or absence) of a pre-existing history of chronic heart failur...

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Autores principales: Schurtz, Guillaume, Delmas, Clément, Fenouillet, Margaux, Roubille, François, Puymirat, Etienne, Bonello, Laurent, Leurent, Guillaume, Verdier, Basile, Levy, Bruno, Ternacle, Julien, Harbaoui, Brahim, Vanzetto, Gerald, Combaret, Nicolas, Lattuca, Benoît, Bruel, Cedric, Bourenne, Jeremy, Labbé, Vincent, Henry, Patrick, Bonnefoy-Cudraz, Éric, Lamblin, Nicolas, Lemesle, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698880/
https://www.ncbi.nlm.nih.gov/pubmed/36430979
http://dx.doi.org/10.3390/life12111844
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author Schurtz, Guillaume
Delmas, Clément
Fenouillet, Margaux
Roubille, François
Puymirat, Etienne
Bonello, Laurent
Leurent, Guillaume
Verdier, Basile
Levy, Bruno
Ternacle, Julien
Harbaoui, Brahim
Vanzetto, Gerald
Combaret, Nicolas
Lattuca, Benoît
Bruel, Cedric
Bourenne, Jeremy
Labbé, Vincent
Henry, Patrick
Bonnefoy-Cudraz, Éric
Lamblin, Nicolas
Lemesle, Gilles
author_facet Schurtz, Guillaume
Delmas, Clément
Fenouillet, Margaux
Roubille, François
Puymirat, Etienne
Bonello, Laurent
Leurent, Guillaume
Verdier, Basile
Levy, Bruno
Ternacle, Julien
Harbaoui, Brahim
Vanzetto, Gerald
Combaret, Nicolas
Lattuca, Benoît
Bruel, Cedric
Bourenne, Jeremy
Labbé, Vincent
Henry, Patrick
Bonnefoy-Cudraz, Éric
Lamblin, Nicolas
Lemesle, Gilles
author_sort Schurtz, Guillaume
collection PubMed
description There is a large heterogeneity among patients presenting with cardiogenic shock (CS). It is crucial to better apprehend this heterogeneity in order to adapt treatments and improve prognoses in these severe patients. Notably, the presence (or absence) of a pre-existing history of chronic heart failure (CHF) at time of CS onset may be a significant part of this heterogeneity, and data focusing on this aspect are lacking. We aimed to compare CS patients with new-onset HF to those with worsening CHF in the multicenter FRENSHOCK registry. Altogether, 772 CS patients were prospectively included: 433 with a previous history of CHF and 339 without. Worsening CHF patients were older (68 +/− 13.4 vs. 62.7 +/− 16.2, p < 0.001) and had a greater burden of extra-cardiac comorbidities. At admission, acute myocardial infarction was predominantly observed in the new-onset HF group (49.9% vs. 25.6%, p < 0.001). When focusing on hemodynamic parameters, worsening CHF patients showed more congestion and higher ventricular filling pressures. Worsening CHF patients experienced higher in-hospital all-cause mortality (31.3% vs. 24.2%, p = 0.029). Our results emphasize the great heterogeneity of the patients presenting with CS. Worsening CHF patients had higher risk profiles, and this translated to a 30% increase in in-hospital all-cause mortality. The heterogeneity of this population prompts us to better determine the phenotype of CS patients to adapt their management.
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spelling pubmed-96988802022-11-26 Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry Schurtz, Guillaume Delmas, Clément Fenouillet, Margaux Roubille, François Puymirat, Etienne Bonello, Laurent Leurent, Guillaume Verdier, Basile Levy, Bruno Ternacle, Julien Harbaoui, Brahim Vanzetto, Gerald Combaret, Nicolas Lattuca, Benoît Bruel, Cedric Bourenne, Jeremy Labbé, Vincent Henry, Patrick Bonnefoy-Cudraz, Éric Lamblin, Nicolas Lemesle, Gilles Life (Basel) Article There is a large heterogeneity among patients presenting with cardiogenic shock (CS). It is crucial to better apprehend this heterogeneity in order to adapt treatments and improve prognoses in these severe patients. Notably, the presence (or absence) of a pre-existing history of chronic heart failure (CHF) at time of CS onset may be a significant part of this heterogeneity, and data focusing on this aspect are lacking. We aimed to compare CS patients with new-onset HF to those with worsening CHF in the multicenter FRENSHOCK registry. Altogether, 772 CS patients were prospectively included: 433 with a previous history of CHF and 339 without. Worsening CHF patients were older (68 +/− 13.4 vs. 62.7 +/− 16.2, p < 0.001) and had a greater burden of extra-cardiac comorbidities. At admission, acute myocardial infarction was predominantly observed in the new-onset HF group (49.9% vs. 25.6%, p < 0.001). When focusing on hemodynamic parameters, worsening CHF patients showed more congestion and higher ventricular filling pressures. Worsening CHF patients experienced higher in-hospital all-cause mortality (31.3% vs. 24.2%, p = 0.029). Our results emphasize the great heterogeneity of the patients presenting with CS. Worsening CHF patients had higher risk profiles, and this translated to a 30% increase in in-hospital all-cause mortality. The heterogeneity of this population prompts us to better determine the phenotype of CS patients to adapt their management. MDPI 2022-11-11 /pmc/articles/PMC9698880/ /pubmed/36430979 http://dx.doi.org/10.3390/life12111844 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schurtz, Guillaume
Delmas, Clément
Fenouillet, Margaux
Roubille, François
Puymirat, Etienne
Bonello, Laurent
Leurent, Guillaume
Verdier, Basile
Levy, Bruno
Ternacle, Julien
Harbaoui, Brahim
Vanzetto, Gerald
Combaret, Nicolas
Lattuca, Benoît
Bruel, Cedric
Bourenne, Jeremy
Labbé, Vincent
Henry, Patrick
Bonnefoy-Cudraz, Éric
Lamblin, Nicolas
Lemesle, Gilles
Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry
title Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry
title_full Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry
title_fullStr Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry
title_full_unstemmed Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry
title_short Impact of Pre-Existing History of Heart Failure on Patient Profile, Therapeutic Management, and Prognosis in Cardiogenic Shock: Insights from the FRENSHOCK Registry
title_sort impact of pre-existing history of heart failure on patient profile, therapeutic management, and prognosis in cardiogenic shock: insights from the frenshock registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698880/
https://www.ncbi.nlm.nih.gov/pubmed/36430979
http://dx.doi.org/10.3390/life12111844
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