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Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8(+) T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation

Naïve CD8(+) T lymphocytes exposed to certain inflammatory cytokines undergo proliferation and display increased sensitivity to antigens. Such ‘cytokine priming’ can promote the activation of potentially autoreactive and antitumor CD8(+) T cells by weak tissue antigens and tumor antigens. To elucida...

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Detalles Bibliográficos
Autores principales:	Quenum, Akouavi Julite Irmine, Santharam, Madanraj Appiya, Ramanathan, Sheela, Ilangumaran, Subburaj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698886/ https://www.ncbi.nlm.nih.gov/pubmed/36430600 http://dx.doi.org/10.3390/ijms232214122

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