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Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis

In this study, we investigated the effect of three different probiotics, namely, a combination of Lactobacillus acidophilus (LA–5) and Bifidobacterium animalis subsp. lactis (BB–12), Saccharomyces boulardii, and Enterococcus faecium L3 on myocardial infarct size in rats with diet-induced obesity (DI...

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Autores principales: Borshchev, Yury Y., Burovenko, Inessa Y., Karaseva, Alena B., Minasian, Sarkis M., Protsak, Egor S., Borshchev, Victor Y., Semenova, Natalia Y., Borshcheva, Olga V., Suvorov, Alexander N., Galagudza, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698902/
https://www.ncbi.nlm.nih.gov/pubmed/36422363
http://dx.doi.org/10.3390/microorganisms10112293
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author Borshchev, Yury Y.
Burovenko, Inessa Y.
Karaseva, Alena B.
Minasian, Sarkis M.
Protsak, Egor S.
Borshchev, Victor Y.
Semenova, Natalia Y.
Borshcheva, Olga V.
Suvorov, Alexander N.
Galagudza, Michael M.
author_facet Borshchev, Yury Y.
Burovenko, Inessa Y.
Karaseva, Alena B.
Minasian, Sarkis M.
Protsak, Egor S.
Borshchev, Victor Y.
Semenova, Natalia Y.
Borshcheva, Olga V.
Suvorov, Alexander N.
Galagudza, Michael M.
author_sort Borshchev, Yury Y.
collection PubMed
description In this study, we investigated the effect of three different probiotics, namely, a combination of Lactobacillus acidophilus (LA–5) and Bifidobacterium animalis subsp. lactis (BB–12), Saccharomyces boulardii, and Enterococcus faecium L3 on myocardial infarct size in rats with diet-induced obesity (DIO) and chemically-induced colitis (CIC). Potential associations between the effects of probiotics on myocardial ischemia-reperfusion injury and gut microbiome patterns as well as the serum levels of pro- and anti-inflammatory cytokines, lipopolysaccharide, and short chain fatty acids were also studied. Intragastric administration of lyophilized Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis at a dose of 1.2 × 10(8) CFU/mL for 15 days resulted in myocardial infarct size reduction in rats with DIO, CIC, and antibiotic-induced dysbiosis. This cardioprotective effect was associated with specific changes in cytokine concentrations, namely reduced levels of IL–1β, TNF–α, IL–2, and IL–8. At the same time, the use of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis was accompanied by a significant reduction in lipopolysaccharide level, suggesting normalization of intestinal epithelial barrier permeability. However, the cardioprotective effect of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis is not secondary to improved healing of the intestinal mucosa in CIC, as evidenced by the lack of difference in histopathological scores.
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spelling pubmed-96989022022-11-26 Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis Borshchev, Yury Y. Burovenko, Inessa Y. Karaseva, Alena B. Minasian, Sarkis M. Protsak, Egor S. Borshchev, Victor Y. Semenova, Natalia Y. Borshcheva, Olga V. Suvorov, Alexander N. Galagudza, Michael M. Microorganisms Article In this study, we investigated the effect of three different probiotics, namely, a combination of Lactobacillus acidophilus (LA–5) and Bifidobacterium animalis subsp. lactis (BB–12), Saccharomyces boulardii, and Enterococcus faecium L3 on myocardial infarct size in rats with diet-induced obesity (DIO) and chemically-induced colitis (CIC). Potential associations between the effects of probiotics on myocardial ischemia-reperfusion injury and gut microbiome patterns as well as the serum levels of pro- and anti-inflammatory cytokines, lipopolysaccharide, and short chain fatty acids were also studied. Intragastric administration of lyophilized Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis at a dose of 1.2 × 10(8) CFU/mL for 15 days resulted in myocardial infarct size reduction in rats with DIO, CIC, and antibiotic-induced dysbiosis. This cardioprotective effect was associated with specific changes in cytokine concentrations, namely reduced levels of IL–1β, TNF–α, IL–2, and IL–8. At the same time, the use of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis was accompanied by a significant reduction in lipopolysaccharide level, suggesting normalization of intestinal epithelial barrier permeability. However, the cardioprotective effect of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis is not secondary to improved healing of the intestinal mucosa in CIC, as evidenced by the lack of difference in histopathological scores. MDPI 2022-11-18 /pmc/articles/PMC9698902/ /pubmed/36422363 http://dx.doi.org/10.3390/microorganisms10112293 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Borshchev, Yury Y.
Burovenko, Inessa Y.
Karaseva, Alena B.
Minasian, Sarkis M.
Protsak, Egor S.
Borshchev, Victor Y.
Semenova, Natalia Y.
Borshcheva, Olga V.
Suvorov, Alexander N.
Galagudza, Michael M.
Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis
title Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis
title_full Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis
title_fullStr Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis
title_full_unstemmed Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis
title_short Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis
title_sort probiotic therapy with lactobacillus acidophilus and bifidobacterium animalis subsp. lactis results in infarct size limitation in rats with obesity and chemically induced colitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698902/
https://www.ncbi.nlm.nih.gov/pubmed/36422363
http://dx.doi.org/10.3390/microorganisms10112293
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