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Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease

MicroRNAs (miRs) are promising diagnostic, prognostic and therapeutic biomolecules for atherosclerotic cardiovascular disease. Atherosclerotic occlusive disease concerns a large population of patients, carrying the highest incidence of fatal and non-fatal adverse events, such as myocardial infarctio...

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Autores principales: Kabłak-Ziembicka, Anna, Badacz, Rafał, Przewłocki, Tadeusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698927/
https://www.ncbi.nlm.nih.gov/pubmed/36431326
http://dx.doi.org/10.3390/jcm11226849
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author Kabłak-Ziembicka, Anna
Badacz, Rafał
Przewłocki, Tadeusz
author_facet Kabłak-Ziembicka, Anna
Badacz, Rafał
Przewłocki, Tadeusz
author_sort Kabłak-Ziembicka, Anna
collection PubMed
description MicroRNAs (miRs) are promising diagnostic, prognostic and therapeutic biomolecules for atherosclerotic cardiovascular disease. Atherosclerotic occlusive disease concerns a large population of patients, carrying the highest incidence of fatal and non-fatal adverse events, such as myocardial infarction, ischemic stroke, and limb ischemia, worldwide. Consistently, miRs are involved in regulation and pathogenesis of atherosclerotic coronary artery disease (CAD), acute coronary syndromes (ACS), both with ST-segment (STEMI) and non-ST segment elevation myocardial infarctions (NSTEMI), as well as cardiac remodeling and fibrosis following ACS. However, the genetic and molecular mechanisms underlying adverse outcomes in CAD are multifactorial, and sometimes difficult to interpret for clinicians. Therefore, in the present review paper we have focused on the clinical meaning and the interpretation of various miRs findings, and their potential application in routine clinical practice.
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spelling pubmed-96989272022-11-26 Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease Kabłak-Ziembicka, Anna Badacz, Rafał Przewłocki, Tadeusz J Clin Med Review MicroRNAs (miRs) are promising diagnostic, prognostic and therapeutic biomolecules for atherosclerotic cardiovascular disease. Atherosclerotic occlusive disease concerns a large population of patients, carrying the highest incidence of fatal and non-fatal adverse events, such as myocardial infarction, ischemic stroke, and limb ischemia, worldwide. Consistently, miRs are involved in regulation and pathogenesis of atherosclerotic coronary artery disease (CAD), acute coronary syndromes (ACS), both with ST-segment (STEMI) and non-ST segment elevation myocardial infarctions (NSTEMI), as well as cardiac remodeling and fibrosis following ACS. However, the genetic and molecular mechanisms underlying adverse outcomes in CAD are multifactorial, and sometimes difficult to interpret for clinicians. Therefore, in the present review paper we have focused on the clinical meaning and the interpretation of various miRs findings, and their potential application in routine clinical practice. MDPI 2022-11-20 /pmc/articles/PMC9698927/ /pubmed/36431326 http://dx.doi.org/10.3390/jcm11226849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kabłak-Ziembicka, Anna
Badacz, Rafał
Przewłocki, Tadeusz
Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease
title Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease
title_full Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease
title_fullStr Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease
title_full_unstemmed Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease
title_short Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease
title_sort clinical application of serum micrornas in atherosclerotic coronary artery disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698927/
https://www.ncbi.nlm.nih.gov/pubmed/36431326
http://dx.doi.org/10.3390/jcm11226849
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