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Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method
This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the pure substance. Fr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699027/ https://www.ncbi.nlm.nih.gov/pubmed/36432005 http://dx.doi.org/10.3390/molecules27227904 |
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author | Rodionova, Oxana Ye. Pomerantsev, Alexey L. Rutledge, Douglas N. |
author_facet | Rodionova, Oxana Ye. Pomerantsev, Alexey L. Rutledge, Douglas N. |
author_sort | Rodionova, Oxana Ye. |
collection | PubMed |
description | This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the pure substance. Fresh samples and samples at different stages of degradation are analyzed. No methods of accelerated aging were applied. Multi-step application of MCR-ALS in its soft version followed by the kinetic modeling of the results helps to propose a generic degradation mechanism; which includes: a global kinetic model; approximations of the NIR spectra of the intermediate and product; rough estimates of rate constants. We study tablets in blister packs; exactly as they are presented in pharmacies; and this is important from a practical point of view. |
format | Online Article Text |
id | pubmed-9699027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96990272022-11-26 Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method Rodionova, Oxana Ye. Pomerantsev, Alexey L. Rutledge, Douglas N. Molecules Article This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the pure substance. Fresh samples and samples at different stages of degradation are analyzed. No methods of accelerated aging were applied. Multi-step application of MCR-ALS in its soft version followed by the kinetic modeling of the results helps to propose a generic degradation mechanism; which includes: a global kinetic model; approximations of the NIR spectra of the intermediate and product; rough estimates of rate constants. We study tablets in blister packs; exactly as they are presented in pharmacies; and this is important from a practical point of view. MDPI 2022-11-15 /pmc/articles/PMC9699027/ /pubmed/36432005 http://dx.doi.org/10.3390/molecules27227904 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rodionova, Oxana Ye. Pomerantsev, Alexey L. Rutledge, Douglas N. Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method |
title | Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method |
title_full | Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method |
title_fullStr | Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method |
title_full_unstemmed | Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method |
title_short | Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method |
title_sort | kinetic model of diclofenac degradation developed using multivariate curve resolution method |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699027/ https://www.ncbi.nlm.nih.gov/pubmed/36432005 http://dx.doi.org/10.3390/molecules27227904 |
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