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Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method

This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the pure substance. Fr...

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Detalles Bibliográficos
Autores principales: Rodionova, Oxana Ye., Pomerantsev, Alexey L., Rutledge, Douglas N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699027/
https://www.ncbi.nlm.nih.gov/pubmed/36432005
http://dx.doi.org/10.3390/molecules27227904
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author Rodionova, Oxana Ye.
Pomerantsev, Alexey L.
Rutledge, Douglas N.
author_facet Rodionova, Oxana Ye.
Pomerantsev, Alexey L.
Rutledge, Douglas N.
author_sort Rodionova, Oxana Ye.
collection PubMed
description This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the pure substance. Fresh samples and samples at different stages of degradation are analyzed. No methods of accelerated aging were applied. Multi-step application of MCR-ALS in its soft version followed by the kinetic modeling of the results helps to propose a generic degradation mechanism; which includes: a global kinetic model; approximations of the NIR spectra of the intermediate and product; rough estimates of rate constants. We study tablets in blister packs; exactly as they are presented in pharmacies; and this is important from a practical point of view.
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spelling pubmed-96990272022-11-26 Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method Rodionova, Oxana Ye. Pomerantsev, Alexey L. Rutledge, Douglas N. Molecules Article This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the pure substance. Fresh samples and samples at different stages of degradation are analyzed. No methods of accelerated aging were applied. Multi-step application of MCR-ALS in its soft version followed by the kinetic modeling of the results helps to propose a generic degradation mechanism; which includes: a global kinetic model; approximations of the NIR spectra of the intermediate and product; rough estimates of rate constants. We study tablets in blister packs; exactly as they are presented in pharmacies; and this is important from a practical point of view. MDPI 2022-11-15 /pmc/articles/PMC9699027/ /pubmed/36432005 http://dx.doi.org/10.3390/molecules27227904 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodionova, Oxana Ye.
Pomerantsev, Alexey L.
Rutledge, Douglas N.
Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method
title Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method
title_full Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method
title_fullStr Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method
title_full_unstemmed Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method
title_short Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method
title_sort kinetic model of diclofenac degradation developed using multivariate curve resolution method
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699027/
https://www.ncbi.nlm.nih.gov/pubmed/36432005
http://dx.doi.org/10.3390/molecules27227904
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