Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity

One of the powerful antioxidants used clinically is Edaravone (EDA). We synthesized a series of new EDA analogs, 4-aminopyrazol-5-ol hydrochlorides, including polyfluoroalkyl derivatives, via the reduction of 4-hydroxyiminopyrazol-5-ones. The primary antioxidant activity of the compounds in comparis...

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Detalles Bibliográficos
Autores principales: Burgart, Yanina V., Makhaeva, Galina F., Krasnykh, Olga P., Borisevich, Sophia S., Agafonova, Natalia A., Kovaleva, Nadezhda V., Boltneva, Natalia P., Rudakova, Elena V., Shchegolkov, Evgeny V., Triandafilova, Galina A., Gazizov, Denis A., Serebryakova, Olga G., Ulitko, Maria V., Khursan, Sergey L., Saloutin, Victor I., Richardson, Rudy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699072/
https://www.ncbi.nlm.nih.gov/pubmed/36431823
http://dx.doi.org/10.3390/molecules27227722

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