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Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor

The mineralocorticoid receptor (MR) acts as an essential regulator of blood pressure, volume status, and electrolyte balance. However, in recent decades, a growing body of evidence has suggested that MR may also have a role in mediating pro-inflammatory, pro-oxidative, and pro-fibrotic changes in se...

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Autores principales: Parasiliti-Caprino, Mirko, Bollati, Martina, Merlo, Fabio Dario, Ghigo, Ezio, Maccario, Mauro, Bo, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699173/
https://www.ncbi.nlm.nih.gov/pubmed/36432422
http://dx.doi.org/10.3390/nu14224735
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author Parasiliti-Caprino, Mirko
Bollati, Martina
Merlo, Fabio Dario
Ghigo, Ezio
Maccario, Mauro
Bo, Simona
author_facet Parasiliti-Caprino, Mirko
Bollati, Martina
Merlo, Fabio Dario
Ghigo, Ezio
Maccario, Mauro
Bo, Simona
author_sort Parasiliti-Caprino, Mirko
collection PubMed
description The mineralocorticoid receptor (MR) acts as an essential regulator of blood pressure, volume status, and electrolyte balance. However, in recent decades, a growing body of evidence has suggested that MR may also have a role in mediating pro-inflammatory, pro-oxidative, and pro-fibrotic changes in several target organs, including the adipose tissue. The finding that MR is overexpressed in the adipose tissue of patients with obesity has led to the hypothesis that this receptor can contribute to adipokine dysregulation and low-grade chronic inflammation, alterations that are linked to the development of obesity-related metabolic and cardiovascular complications. Moreover, several studies in animal models have investigated the role of MR antagonists (MRAs) in preventing the metabolic alterations observed in obesity. In the present review we will focus on the potential mechanisms by which MR activation can contribute to adipose tissue dysfunction in obesity and on the possible beneficial effects of MRAs in this setting.
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spelling pubmed-96991732022-11-26 Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor Parasiliti-Caprino, Mirko Bollati, Martina Merlo, Fabio Dario Ghigo, Ezio Maccario, Mauro Bo, Simona Nutrients Review The mineralocorticoid receptor (MR) acts as an essential regulator of blood pressure, volume status, and electrolyte balance. However, in recent decades, a growing body of evidence has suggested that MR may also have a role in mediating pro-inflammatory, pro-oxidative, and pro-fibrotic changes in several target organs, including the adipose tissue. The finding that MR is overexpressed in the adipose tissue of patients with obesity has led to the hypothesis that this receptor can contribute to adipokine dysregulation and low-grade chronic inflammation, alterations that are linked to the development of obesity-related metabolic and cardiovascular complications. Moreover, several studies in animal models have investigated the role of MR antagonists (MRAs) in preventing the metabolic alterations observed in obesity. In the present review we will focus on the potential mechanisms by which MR activation can contribute to adipose tissue dysfunction in obesity and on the possible beneficial effects of MRAs in this setting. MDPI 2022-11-09 /pmc/articles/PMC9699173/ /pubmed/36432422 http://dx.doi.org/10.3390/nu14224735 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Parasiliti-Caprino, Mirko
Bollati, Martina
Merlo, Fabio Dario
Ghigo, Ezio
Maccario, Mauro
Bo, Simona
Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor
title Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor
title_full Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor
title_fullStr Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor
title_full_unstemmed Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor
title_short Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor
title_sort adipose tissue dysfunction in obesity: role of mineralocorticoid receptor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699173/
https://www.ncbi.nlm.nih.gov/pubmed/36432422
http://dx.doi.org/10.3390/nu14224735
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