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Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients

Oxidative stress is induced by tobacco smoking and is also associated with exposure to air pollution, which are two of the most important risk factors for chronic obstructive pulmonary disease (COPD). The aim of this study was to correlate tobacco use and exposure to air pollution with oxidative str...

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Autores principales: Buculei, Ioana, Dobrin, Mona Elisabeta, Matei, Daniela, Onu, Ilie, Vicol, Cristina, Cioroiu, Ionel Bogdan, Niculaua, Marius, Iordan, Daniel Andrei, Cernomaz, Andrei, Trofor, Antigona Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699204/
https://www.ncbi.nlm.nih.gov/pubmed/36422889
http://dx.doi.org/10.3390/toxics10110681
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author Buculei, Ioana
Dobrin, Mona Elisabeta
Matei, Daniela
Onu, Ilie
Vicol, Cristina
Cioroiu, Ionel Bogdan
Niculaua, Marius
Iordan, Daniel Andrei
Cernomaz, Andrei
Trofor, Antigona Carmen
author_facet Buculei, Ioana
Dobrin, Mona Elisabeta
Matei, Daniela
Onu, Ilie
Vicol, Cristina
Cioroiu, Ionel Bogdan
Niculaua, Marius
Iordan, Daniel Andrei
Cernomaz, Andrei
Trofor, Antigona Carmen
author_sort Buculei, Ioana
collection PubMed
description Oxidative stress is induced by tobacco smoking and is also associated with exposure to air pollution, which are two of the most important risk factors for chronic obstructive pulmonary disease (COPD). The aim of this study was to correlate tobacco use and exposure to air pollution with oxidative stress markers useful in clinical practice in patients with COPD. A total of 102 patients were included and the levels of polycyclic aromatic hydrocarbons (PAHs), malondialdehyde, uric acid and number of packs-years (PY) were determined. Also, six different ratios were used to assess the source of exposure. The results obtained in this study show an admission of pollutants according to smoking status (former smokers/smoker/non-smokers) quantified in average total concentrations for the group of patients with COPD of 4.12 ng/mL, 6.76 ng/mL, 6.04 ng/mL. The six ratios used show that in COPD, the content of PAHs in the blood could be a result of diesel emissions and fuel combustion. Uric acid levels were lower in the smoker group of COPD patients (mean = 5.21 mg/dL), which indicates that oxidative stress is intensified with each cigarette smoked. Additionally, high concentrations of malondialdehyde were quantified for smoking patients diagnosed with COPD (mean = 2.72 µmol/L) compared to former smokers (mean = 2.43 µmol/L) and non-smoking (mean = 2.32 µmol/L) patients, which is another indicator of the implication of smoking in oxidative stress in COPD patients.
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spelling pubmed-96992042022-11-26 Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients Buculei, Ioana Dobrin, Mona Elisabeta Matei, Daniela Onu, Ilie Vicol, Cristina Cioroiu, Ionel Bogdan Niculaua, Marius Iordan, Daniel Andrei Cernomaz, Andrei Trofor, Antigona Carmen Toxics Article Oxidative stress is induced by tobacco smoking and is also associated with exposure to air pollution, which are two of the most important risk factors for chronic obstructive pulmonary disease (COPD). The aim of this study was to correlate tobacco use and exposure to air pollution with oxidative stress markers useful in clinical practice in patients with COPD. A total of 102 patients were included and the levels of polycyclic aromatic hydrocarbons (PAHs), malondialdehyde, uric acid and number of packs-years (PY) were determined. Also, six different ratios were used to assess the source of exposure. The results obtained in this study show an admission of pollutants according to smoking status (former smokers/smoker/non-smokers) quantified in average total concentrations for the group of patients with COPD of 4.12 ng/mL, 6.76 ng/mL, 6.04 ng/mL. The six ratios used show that in COPD, the content of PAHs in the blood could be a result of diesel emissions and fuel combustion. Uric acid levels were lower in the smoker group of COPD patients (mean = 5.21 mg/dL), which indicates that oxidative stress is intensified with each cigarette smoked. Additionally, high concentrations of malondialdehyde were quantified for smoking patients diagnosed with COPD (mean = 2.72 µmol/L) compared to former smokers (mean = 2.43 µmol/L) and non-smoking (mean = 2.32 µmol/L) patients, which is another indicator of the implication of smoking in oxidative stress in COPD patients. MDPI 2022-11-11 /pmc/articles/PMC9699204/ /pubmed/36422889 http://dx.doi.org/10.3390/toxics10110681 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Buculei, Ioana
Dobrin, Mona Elisabeta
Matei, Daniela
Onu, Ilie
Vicol, Cristina
Cioroiu, Ionel Bogdan
Niculaua, Marius
Iordan, Daniel Andrei
Cernomaz, Andrei
Trofor, Antigona Carmen
Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients
title Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients
title_full Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients
title_fullStr Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients
title_full_unstemmed Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients
title_short Polycyclic Aromatic Hydrocarbons Induced by Smoking and Air Pollution: Correlation with Oxidative Stress in Chronic Obstructive Pulmonary Disease Patients
title_sort polycyclic aromatic hydrocarbons induced by smoking and air pollution: correlation with oxidative stress in chronic obstructive pulmonary disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699204/
https://www.ncbi.nlm.nih.gov/pubmed/36422889
http://dx.doi.org/10.3390/toxics10110681
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