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Petroleum in Pesticides: A Need to Change Regulatory Toxicology

Toxicological investigations of pesticides largely focus on the declared active ingredient, which constitutes only between a few percent to around 50% of the total formulation. The complete formulations are unknown. For each declared active ingredient, there are dozens or hundreds of formulations. W...

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Autores principales: Jungers, Gérald, Portet-Koltalo, Florence, Cosme, Julie, Seralini, Gilles-Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699208/
https://www.ncbi.nlm.nih.gov/pubmed/36355961
http://dx.doi.org/10.3390/toxics10110670
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author Jungers, Gérald
Portet-Koltalo, Florence
Cosme, Julie
Seralini, Gilles-Eric
author_facet Jungers, Gérald
Portet-Koltalo, Florence
Cosme, Julie
Seralini, Gilles-Eric
author_sort Jungers, Gérald
collection PubMed
description Toxicological investigations of pesticides largely focus on the declared active ingredient, which constitutes only between a few percent to around 50% of the total formulation. The complete formulations are unknown. For each declared active ingredient, there are dozens or hundreds of formulations. We demonstrate that petroleum has always been and is still always in pesticides. Gas chromatography and mass spectrometry (GC-MS) were applied for 24 pesticides. The measured compounds were the 16-priority polycyclic aromatic hydrocarbons (PAHs). The ratio of the PAHs to the threshold of toxicity was from 2.16 to 8288 times. The levels and distribution of PAHs per pesticide were different. Petroleum residues appear to be a waste product. The declared active component is taken alone for toxicity calculations, such as the acceptable daily intake (ADI). The PAHs with 2–3 cycles are more represented in pesticides than those with 4–6 cycles, which underlines that the petroleum residues appear to come mainly from crude unburned material. The ADI should be divided by 1000 if it is considered that petroleum residues amplify the toxicity by 1000. The admixture of PAHs in pesticides can be highly carcinogenic or toxic in the long term, even more than the declared active ingredient itself.
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spelling pubmed-96992082022-11-26 Petroleum in Pesticides: A Need to Change Regulatory Toxicology Jungers, Gérald Portet-Koltalo, Florence Cosme, Julie Seralini, Gilles-Eric Toxics Article Toxicological investigations of pesticides largely focus on the declared active ingredient, which constitutes only between a few percent to around 50% of the total formulation. The complete formulations are unknown. For each declared active ingredient, there are dozens or hundreds of formulations. We demonstrate that petroleum has always been and is still always in pesticides. Gas chromatography and mass spectrometry (GC-MS) were applied for 24 pesticides. The measured compounds were the 16-priority polycyclic aromatic hydrocarbons (PAHs). The ratio of the PAHs to the threshold of toxicity was from 2.16 to 8288 times. The levels and distribution of PAHs per pesticide were different. Petroleum residues appear to be a waste product. The declared active component is taken alone for toxicity calculations, such as the acceptable daily intake (ADI). The PAHs with 2–3 cycles are more represented in pesticides than those with 4–6 cycles, which underlines that the petroleum residues appear to come mainly from crude unburned material. The ADI should be divided by 1000 if it is considered that petroleum residues amplify the toxicity by 1000. The admixture of PAHs in pesticides can be highly carcinogenic or toxic in the long term, even more than the declared active ingredient itself. MDPI 2022-11-06 /pmc/articles/PMC9699208/ /pubmed/36355961 http://dx.doi.org/10.3390/toxics10110670 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jungers, Gérald
Portet-Koltalo, Florence
Cosme, Julie
Seralini, Gilles-Eric
Petroleum in Pesticides: A Need to Change Regulatory Toxicology
title Petroleum in Pesticides: A Need to Change Regulatory Toxicology
title_full Petroleum in Pesticides: A Need to Change Regulatory Toxicology
title_fullStr Petroleum in Pesticides: A Need to Change Regulatory Toxicology
title_full_unstemmed Petroleum in Pesticides: A Need to Change Regulatory Toxicology
title_short Petroleum in Pesticides: A Need to Change Regulatory Toxicology
title_sort petroleum in pesticides: a need to change regulatory toxicology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699208/
https://www.ncbi.nlm.nih.gov/pubmed/36355961
http://dx.doi.org/10.3390/toxics10110670
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