Cargando…

Survival and Chemosensitivity in Advanced High Grade Serous Epithelial Ovarian Cancer Patients with and without a BRCA Germline Mutation: More Evidence for Shifting the Paradigm towards Complete Surgical Cytoreduction

Background and Objectives: Approximately 10–15% of high-grade serous ovarian cancer (HGSOC) cases are related to BRCA germline mutations. Better survival rates and increased chemosensitivity are reported in patients with a BRCA 1/2 germline mutation. However, the FIGO stage and histopathological ent...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Jong, Diederick, Otify, Mohamed, Chen, Inga, Jackson, David, Jayasinghe, Kelum, Nugent, David, Thangavelu, Amudha, Theophilou, Georgios, Laios, Alexandros
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699274/ https://www.ncbi.nlm.nih.gov/pubmed/36363568 http://dx.doi.org/10.3390/medicina58111611

Ejemplares similares

The Uncertain Benefit of Adjuvant Chemotherapy in Advanced Low-Grade Serous Ovarian Cancer and the Pivotal Role of Surgical Cytoreduction
por: Johnson, Racheal Louise, et al.
Publicado: (2021)

RoBERTa-Assisted Outcome Prediction in Ovarian Cancer Cytoreductive Surgery Using Operative Notes
por: Laios, Alexandros, et al.
Publicado: (2023)

Feature Selection is Critical for 2-Year Prognosis in Advanced Stage High Grade Serous Ovarian Cancer by Using Machine Learning
por: Laios, Alexandros, et al.
Publicado: (2021)

Prerequisites to improve surgical cytoreduction in FIGO stage III/IV epithelial ovarian cancer and subsequent clinical ramifications
por: de Jong, Diederick, et al.
Publicado: (2023)

Explainable Artificial Intelligence for Prediction of Complete Surgical Cytoreduction in Advanced-Stage Epithelial Ovarian Cancer
por: Laios, Alexandros, et al.
Publicado: (2022)

Machine Learning-Based Risk Prediction of Critical Care Unit Admission for Advanced Stage High Grade Serous Ovarian Cancer Patients Undergoing Cytoreductive Surgery: The Leeds-Natal Score
por: Laios, Alexandros, et al.
Publicado: (2021)

Development of a Novel Intra-Operative Score to Record Diseases’ Anatomic Fingerprints (ANAFI Score) for the Prediction of Complete Cytoreduction in Advanced-Stage Ovarian Cancer by Using Machine Learning and Explainable Artificial Intelligence
por: Laios, Alexandros, et al.
Publicado: (2023)

Exploring the Potential Role of Upper Abdominal Peritonectomy in Advanced Ovarian Cancer Cytoreductive Surgery Using Explainable Artificial Intelligence
por: Laios, Alexandros, et al.
Publicado: (2023)

Stratification of Length of Stay Prediction following Surgical Cytoreduction in Advanced High-Grade Serous Ovarian Cancer Patients Using Artificial Intelligence; the Leeds L-AI-OS Score
por: Laios, Alexandros, et al.
Publicado: (2022)

Predicting complete cytoreduction for advanced ovarian cancer patients using nearest-neighbor models
por: Laios, Alexandros, et al.
Publicado: (2020)

Factors Predicting Surgical Effort Using Explainable Artificial Intelligence in Advanced Stage Epithelial Ovarian Cancer
por: Laios, Alexandros, et al.
Publicado: (2022)

Immune Checkpoint Inhibitors Targeting the PD-1/PD-L1 Pathway in Advanced, Recurrent Endometrial Cancer: A Scoping Review with SWOT Analysis
por: Johnson, Racheal Louise, et al.
Publicado: (2023)

The Future of AI in Ovarian Cancer Research: The Large Language Models Perspective
por: Laios, Alexandros, et al.
Publicado: (2023)

Barriers to Immunotherapy in Ovarian Cancer: Metabolic, Genomic, and Immune Perturbations in the Tumour Microenvironment
por: Johnson, Racheal Louise, et al.
Publicado: (2021)

New Paradigms for Cytoreductive Nephrectomy
por: Lichtbroun, Benjamin J., et al.
Publicado: (2022)

Outcomes of ovarian transposition in cervical cancer; an updated meta-analysis
por: Laios, Alexandros, et al.
Publicado: (2022)

Breast Cancer Patients at Increased Risk of Developing Type II Endometrial Cancer: Relative and Absolute Risk Estimation and Implications for Counseling
por: Portela, Sara, et al.
Publicado: (2021)

Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer
por: Eoh, Kyung Jin, et al.
Publicado: (2020)

Germline and tumor BRCA1/2 mutations in Chinese high grade serous ovarian cancer patients
por: Ji, Gang, et al.
Publicado: (2021)

Differential Sensitivity of Germline and Somatic BRCA Variants to PARP Inhibitor in High-Grade Serous Ovarian Cancer
por: Vendrell, Julie A., et al.
Publicado: (2023)

Beauty is in the explainable artificial intelligence (XAI) of the “agnostic” beholder
por: Laios, Alexandros, et al.
Publicado: (2023)

Melanoma predisposition—A limited role for germline BRCA1 and BRCA2 variants
por: Adams, David J., et al.
Publicado: (2019)

Fatal cardiac tamponade following cytoreductive surgery for serous carcinoma of the ovary
por: English, Emily, et al.
Publicado: (2015)

The germline mutational landscape of BRCA1 and BRCA2 in Brazil
por: Palmero, Edenir Inêz, et al.
Publicado: (2018)

Case Report: Double Germline Mutations in BRCA1 and MSH2 in a Patient With Mixed Serous-Endometrioid Endometrial Carcinoma
por: Zheng, Hong, et al.
Publicado: (2020)

Recurrent uterine serous carcinoma with a germline pathogenic BRCA2 variant treated using olaparib: A case report
por: Inoue, Kayo, et al.
Publicado: (2020)

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
por: Maxwell, Kara N., et al.
Publicado: (2017)

Impact of veliparib, paclitaxel dosing regimen, and germline BRCA status on the primary treatment of serous ovarian cancer – an ancillary data analysis of the VELIA trial
por: Aghajanian, Carol, et al.
Publicado: (2022)

Investigating the effect of optimal cytoreduction in the context of platinum sensitivity in high‐grade serous ovarian cancer
por: Cardillo, Nicholas, et al.
Publicado: (2022)

Integrated Clinical and Genomic Models to Predict Optimal Cytoreduction in High-Grade Serous Ovarian Cancer
por: Cardillo, Nicholas, et al.
Publicado: (2022)

BRCA1 and BRCA2 germline mutation analysis in the Indonesian population
por: Purnomosari, Dewajani, et al.
Publicado: (2007)

Cytoreductive prostatectomy: Evidence in support of a new surgical paradigm (Review)
por: FAIENA, IZAK, et al.
Publicado: (2014)

Molecular and phenotypic characteristics influencing the degree of cytoreduction in high‐grade serous ovarian carcinomas
por: Torkildsen, Cecilie Fredvik, et al.
Publicado: (2023)

BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells
por: Tassone, P, et al.
Publicado: (2003)

Evaluation of models to predict BRCA germline mutations
por: Kang, H H, et al.
Publicado: (2006)

The occurrence of germline BRCA1 and BRCA2 sequence alterations in Slovenian population
por: Stegel, Vida, et al.
Publicado: (2011)

Contribution of germline BRCA1 and BRCA2 sequence alterations to breast cancer in Northern India
por: Saxena, Sunita, et al.
Publicado: (2006)

Invasive bilateral breast cancer and high grade serous ovarian cancer with BRCA1-germline mutation and brainstem metastasis under PARP inhibitors
por: Zahari, Mihaela Mărioara, et al.
Publicado: (2021)

Germline development in amniotes: A paradigm shift in primordial germ cell specification
por: Bertocchini, Federica, et al.
Publicado: (2016)

BRCA and Early Events in the Development of Serous Ovarian Cancer
por: George, Sophia H. L., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6qlscaailqobm6gj33tp6gm7ff