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Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population
Background: Brugada syndrome (BrS) is an inheritable arrhythmia syndrome that can lead to sudden cardiac death in patients while the heart structure is normal. However, the genetic background of more than 65% of BrS probands remains unclear. Objectives: The purpose of this study is to report the var...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699371/ https://www.ncbi.nlm.nih.gov/pubmed/36354768 http://dx.doi.org/10.3390/jcdd9110369 |
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author | Wang, Lin-Lin Chen, Yang-Hui Sun, Yang Huang, Man Wei, Hao-Ran Liu, Hao Xu, Ke Song, Xiu-Li Chen, Peng Tan, Lun Huang, Jin Li, Zong-Zhe Li, Rui Yu, Ting Ma, Fei Ding, Hu Wang, Yan Wang, Dao-Wen Wang, Hong Zhao, Chun-Xia |
author_facet | Wang, Lin-Lin Chen, Yang-Hui Sun, Yang Huang, Man Wei, Hao-Ran Liu, Hao Xu, Ke Song, Xiu-Li Chen, Peng Tan, Lun Huang, Jin Li, Zong-Zhe Li, Rui Yu, Ting Ma, Fei Ding, Hu Wang, Yan Wang, Dao-Wen Wang, Hong Zhao, Chun-Xia |
author_sort | Wang, Lin-Lin |
collection | PubMed |
description | Background: Brugada syndrome (BrS) is an inheritable arrhythmia syndrome that can lead to sudden cardiac death in patients while the heart structure is normal. However, the genetic background of more than 65% of BrS probands remains unclear. Objectives: The purpose of this study is to report the variant spectrum in a Chinese cohort with suspected BrS and to analyze their distinct clinical and electrocardiographic features. Methods: Patients with suspected BrS from Tongji Hospital between 2008 and 2021 were analyzed retrospectively. Results: A total of 79 probands were included in this study. Patients with type 1 BrS electrocardiogram (ECG) had a prolonged QRS duration compared to patients with type 2/3 BrS ECG. Of them, 59 probands underwent genetic testing. Twenty-five patients (42.37%) showed abnormal genetic testing results, and eight of them (13.56%) carried pathogenic/likely pathogenic (P/LP) mutations. Mutation carriers presented much more prominent depolarization and repolarization abnormalities than non-carriers, including a prolonged P-wave duration, QRS duration, QTc interval, decreased QRS amplitude, and deviation of the electrocardiographic axes (T-wave axis and R-wave axis). Furthermore, our study identified four novel P/LP mutations: Q3508X in TTN, A990G in KCNH2, G1220E, and D372H (in a representative pedigree) in SCN5A. Conclusions: Our study showed the variant spectrum of a suspected Chinese BrS cohort, and we identified four novel P/LP mutations in TTN, KCNH2, and SCN5A. |
format | Online Article Text |
id | pubmed-9699371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96993712022-11-26 Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population Wang, Lin-Lin Chen, Yang-Hui Sun, Yang Huang, Man Wei, Hao-Ran Liu, Hao Xu, Ke Song, Xiu-Li Chen, Peng Tan, Lun Huang, Jin Li, Zong-Zhe Li, Rui Yu, Ting Ma, Fei Ding, Hu Wang, Yan Wang, Dao-Wen Wang, Hong Zhao, Chun-Xia J Cardiovasc Dev Dis Article Background: Brugada syndrome (BrS) is an inheritable arrhythmia syndrome that can lead to sudden cardiac death in patients while the heart structure is normal. However, the genetic background of more than 65% of BrS probands remains unclear. Objectives: The purpose of this study is to report the variant spectrum in a Chinese cohort with suspected BrS and to analyze their distinct clinical and electrocardiographic features. Methods: Patients with suspected BrS from Tongji Hospital between 2008 and 2021 were analyzed retrospectively. Results: A total of 79 probands were included in this study. Patients with type 1 BrS electrocardiogram (ECG) had a prolonged QRS duration compared to patients with type 2/3 BrS ECG. Of them, 59 probands underwent genetic testing. Twenty-five patients (42.37%) showed abnormal genetic testing results, and eight of them (13.56%) carried pathogenic/likely pathogenic (P/LP) mutations. Mutation carriers presented much more prominent depolarization and repolarization abnormalities than non-carriers, including a prolonged P-wave duration, QRS duration, QTc interval, decreased QRS amplitude, and deviation of the electrocardiographic axes (T-wave axis and R-wave axis). Furthermore, our study identified four novel P/LP mutations: Q3508X in TTN, A990G in KCNH2, G1220E, and D372H (in a representative pedigree) in SCN5A. Conclusions: Our study showed the variant spectrum of a suspected Chinese BrS cohort, and we identified four novel P/LP mutations in TTN, KCNH2, and SCN5A. MDPI 2022-10-28 /pmc/articles/PMC9699371/ /pubmed/36354768 http://dx.doi.org/10.3390/jcdd9110369 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Lin-Lin Chen, Yang-Hui Sun, Yang Huang, Man Wei, Hao-Ran Liu, Hao Xu, Ke Song, Xiu-Li Chen, Peng Tan, Lun Huang, Jin Li, Zong-Zhe Li, Rui Yu, Ting Ma, Fei Ding, Hu Wang, Yan Wang, Dao-Wen Wang, Hong Zhao, Chun-Xia Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population |
title | Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population |
title_full | Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population |
title_fullStr | Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population |
title_full_unstemmed | Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population |
title_short | Genetic Profile and Clinical Characteristics of Brugada Syndrome in the Chinese Population |
title_sort | genetic profile and clinical characteristics of brugada syndrome in the chinese population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699371/ https://www.ncbi.nlm.nih.gov/pubmed/36354768 http://dx.doi.org/10.3390/jcdd9110369 |
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