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Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes

Molecular imaging has demonstrated promise for evaluating the expression levels of biomarkers for the early prediction of tumor progression and metastasis. However, most of the commonly used molecular imaging modalities are relatively single and have difficulties imaging complex biological processes...

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Detalles Bibliográficos
Autores principales: Wang, Jieqiong, Wang, Yuanyuan, Jia, Jie, Liu, Chenxing, Ni, Dong, Sun, Litao, Guo, Zhijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699378/
https://www.ncbi.nlm.nih.gov/pubmed/36432701
http://dx.doi.org/10.3390/pharmaceutics14112510
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author Wang, Jieqiong
Wang, Yuanyuan
Jia, Jie
Liu, Chenxing
Ni, Dong
Sun, Litao
Guo, Zhijie
author_facet Wang, Jieqiong
Wang, Yuanyuan
Jia, Jie
Liu, Chenxing
Ni, Dong
Sun, Litao
Guo, Zhijie
author_sort Wang, Jieqiong
collection PubMed
description Molecular imaging has demonstrated promise for evaluating the expression levels of biomarkers for the early prediction of tumor progression and metastasis. However, most of the commonly used molecular imaging modalities are relatively single and have difficulties imaging complex biological processes. Here, we fabricated αvβ3-integrin-targeted quantum-dots-loaded liposome–microbubble (iRGD-QDLM) complexes that combined ultrasound imaging with optical imaging. The resulting iRGD-QDLM has excellent binding capability to 4T1 breast cancer cells. Ultrasound molecular imaging of 4T1 tumors demonstrated that significantly enhanced ultrasound molecular signals could be observed in comparison with non-targeted QDLM. Importantly, our study also suggested that iRGD-QDL on the surface of microbubbles could be delivered into a tumor by ultrasound-mediated microbubble destruction and adhered to αvβ3 integrin on breast cancer cells, achieving transvascular fluorescent imaging. Our study provides a novel approach to dual-modality molecular imaging of αvβ3 integrin in the tumor tissue.
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spelling pubmed-96993782022-11-26 Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes Wang, Jieqiong Wang, Yuanyuan Jia, Jie Liu, Chenxing Ni, Dong Sun, Litao Guo, Zhijie Pharmaceutics Article Molecular imaging has demonstrated promise for evaluating the expression levels of biomarkers for the early prediction of tumor progression and metastasis. However, most of the commonly used molecular imaging modalities are relatively single and have difficulties imaging complex biological processes. Here, we fabricated αvβ3-integrin-targeted quantum-dots-loaded liposome–microbubble (iRGD-QDLM) complexes that combined ultrasound imaging with optical imaging. The resulting iRGD-QDLM has excellent binding capability to 4T1 breast cancer cells. Ultrasound molecular imaging of 4T1 tumors demonstrated that significantly enhanced ultrasound molecular signals could be observed in comparison with non-targeted QDLM. Importantly, our study also suggested that iRGD-QDL on the surface of microbubbles could be delivered into a tumor by ultrasound-mediated microbubble destruction and adhered to αvβ3 integrin on breast cancer cells, achieving transvascular fluorescent imaging. Our study provides a novel approach to dual-modality molecular imaging of αvβ3 integrin in the tumor tissue. MDPI 2022-11-18 /pmc/articles/PMC9699378/ /pubmed/36432701 http://dx.doi.org/10.3390/pharmaceutics14112510 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Jieqiong
Wang, Yuanyuan
Jia, Jie
Liu, Chenxing
Ni, Dong
Sun, Litao
Guo, Zhijie
Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes
title Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes
title_full Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes
title_fullStr Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes
title_full_unstemmed Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes
title_short Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes
title_sort dual-modality molecular imaging of tumor via quantum dots-liposome–microbubble complexes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699378/
https://www.ncbi.nlm.nih.gov/pubmed/36432701
http://dx.doi.org/10.3390/pharmaceutics14112510
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