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Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes
Molecular imaging has demonstrated promise for evaluating the expression levels of biomarkers for the early prediction of tumor progression and metastasis. However, most of the commonly used molecular imaging modalities are relatively single and have difficulties imaging complex biological processes...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699378/ https://www.ncbi.nlm.nih.gov/pubmed/36432701 http://dx.doi.org/10.3390/pharmaceutics14112510 |
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author | Wang, Jieqiong Wang, Yuanyuan Jia, Jie Liu, Chenxing Ni, Dong Sun, Litao Guo, Zhijie |
author_facet | Wang, Jieqiong Wang, Yuanyuan Jia, Jie Liu, Chenxing Ni, Dong Sun, Litao Guo, Zhijie |
author_sort | Wang, Jieqiong |
collection | PubMed |
description | Molecular imaging has demonstrated promise for evaluating the expression levels of biomarkers for the early prediction of tumor progression and metastasis. However, most of the commonly used molecular imaging modalities are relatively single and have difficulties imaging complex biological processes. Here, we fabricated αvβ3-integrin-targeted quantum-dots-loaded liposome–microbubble (iRGD-QDLM) complexes that combined ultrasound imaging with optical imaging. The resulting iRGD-QDLM has excellent binding capability to 4T1 breast cancer cells. Ultrasound molecular imaging of 4T1 tumors demonstrated that significantly enhanced ultrasound molecular signals could be observed in comparison with non-targeted QDLM. Importantly, our study also suggested that iRGD-QDL on the surface of microbubbles could be delivered into a tumor by ultrasound-mediated microbubble destruction and adhered to αvβ3 integrin on breast cancer cells, achieving transvascular fluorescent imaging. Our study provides a novel approach to dual-modality molecular imaging of αvβ3 integrin in the tumor tissue. |
format | Online Article Text |
id | pubmed-9699378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96993782022-11-26 Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes Wang, Jieqiong Wang, Yuanyuan Jia, Jie Liu, Chenxing Ni, Dong Sun, Litao Guo, Zhijie Pharmaceutics Article Molecular imaging has demonstrated promise for evaluating the expression levels of biomarkers for the early prediction of tumor progression and metastasis. However, most of the commonly used molecular imaging modalities are relatively single and have difficulties imaging complex biological processes. Here, we fabricated αvβ3-integrin-targeted quantum-dots-loaded liposome–microbubble (iRGD-QDLM) complexes that combined ultrasound imaging with optical imaging. The resulting iRGD-QDLM has excellent binding capability to 4T1 breast cancer cells. Ultrasound molecular imaging of 4T1 tumors demonstrated that significantly enhanced ultrasound molecular signals could be observed in comparison with non-targeted QDLM. Importantly, our study also suggested that iRGD-QDL on the surface of microbubbles could be delivered into a tumor by ultrasound-mediated microbubble destruction and adhered to αvβ3 integrin on breast cancer cells, achieving transvascular fluorescent imaging. Our study provides a novel approach to dual-modality molecular imaging of αvβ3 integrin in the tumor tissue. MDPI 2022-11-18 /pmc/articles/PMC9699378/ /pubmed/36432701 http://dx.doi.org/10.3390/pharmaceutics14112510 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Jieqiong Wang, Yuanyuan Jia, Jie Liu, Chenxing Ni, Dong Sun, Litao Guo, Zhijie Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes |
title | Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes |
title_full | Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes |
title_fullStr | Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes |
title_full_unstemmed | Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes |
title_short | Dual-Modality Molecular Imaging of Tumor via Quantum Dots-Liposome–Microbubble Complexes |
title_sort | dual-modality molecular imaging of tumor via quantum dots-liposome–microbubble complexes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699378/ https://www.ncbi.nlm.nih.gov/pubmed/36432701 http://dx.doi.org/10.3390/pharmaceutics14112510 |
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