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pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules

Gastrodiae rhizoma (GR) formula granules and preparations have been used as a popular traditional Chinese medicine for clinical treatment since they have good pharmacological activity to treat nervous system diseases. Gastrodin and parishins have been the main active components in aqueous extracts f...

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Autores principales: Xie, Shuting, Min, Ke, Li, Hai, Wang, Ying, Liu, Mincong, Ma, Ming, Zhou, Desheng, Tu, Haijun, Chen, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699468/
https://www.ncbi.nlm.nih.gov/pubmed/36432193
http://dx.doi.org/10.3390/molecules27228091
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author Xie, Shuting
Min, Ke
Li, Hai
Wang, Ying
Liu, Mincong
Ma, Ming
Zhou, Desheng
Tu, Haijun
Chen, Bo
author_facet Xie, Shuting
Min, Ke
Li, Hai
Wang, Ying
Liu, Mincong
Ma, Ming
Zhou, Desheng
Tu, Haijun
Chen, Bo
author_sort Xie, Shuting
collection PubMed
description Gastrodiae rhizoma (GR) formula granules and preparations have been used as a popular traditional Chinese medicine for clinical treatment since they have good pharmacological activity to treat nervous system diseases. Gastrodin and parishins have been the main active components in aqueous extracts for GR formula granules, but their pharmacological activities and metabolism are different. For quality control of the extracts, the extraction conditions should be investigated to accurately control the contents of two kinds of components. In this paper, the transfer rate of six index components (including gastrodin, p-hydroxybenzyl alcohol, parishin A, parishin B, parishin C, and parishin E) obtained by HPLC were used as indicators to investigate the effect of pH on the GR extraction process. The results demonstrated that pH is a key factor for preventing transforming parishins into gastrodin and maintaining high content of parishins in the extracts. It can be concluded that the weak acid environment could improve the transfer rate of parishins, thus ensuring the gastrodin and parishins consistency between GR raw materials and its aqueous extracts. Therefore, pH is an essential condition for accurate quality control of the extracts.
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spelling pubmed-96994682022-11-26 pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules Xie, Shuting Min, Ke Li, Hai Wang, Ying Liu, Mincong Ma, Ming Zhou, Desheng Tu, Haijun Chen, Bo Molecules Article Gastrodiae rhizoma (GR) formula granules and preparations have been used as a popular traditional Chinese medicine for clinical treatment since they have good pharmacological activity to treat nervous system diseases. Gastrodin and parishins have been the main active components in aqueous extracts for GR formula granules, but their pharmacological activities and metabolism are different. For quality control of the extracts, the extraction conditions should be investigated to accurately control the contents of two kinds of components. In this paper, the transfer rate of six index components (including gastrodin, p-hydroxybenzyl alcohol, parishin A, parishin B, parishin C, and parishin E) obtained by HPLC were used as indicators to investigate the effect of pH on the GR extraction process. The results demonstrated that pH is a key factor for preventing transforming parishins into gastrodin and maintaining high content of parishins in the extracts. It can be concluded that the weak acid environment could improve the transfer rate of parishins, thus ensuring the gastrodin and parishins consistency between GR raw materials and its aqueous extracts. Therefore, pH is an essential condition for accurate quality control of the extracts. MDPI 2022-11-21 /pmc/articles/PMC9699468/ /pubmed/36432193 http://dx.doi.org/10.3390/molecules27228091 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xie, Shuting
Min, Ke
Li, Hai
Wang, Ying
Liu, Mincong
Ma, Ming
Zhou, Desheng
Tu, Haijun
Chen, Bo
pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules
title pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules
title_full pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules
title_fullStr pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules
title_full_unstemmed pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules
title_short pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules
title_sort ph as a key factor for the quality assurance of the preparation of gastrodiae rhizoma formula granules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699468/
https://www.ncbi.nlm.nih.gov/pubmed/36432193
http://dx.doi.org/10.3390/molecules27228091
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