Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments

Epstein–Barr virus (EBV) is one of eight known herpesviruses with the potential to infect humans. Globally, it is estimated that between 90–95% of the population has been infected with EBV. EBV is an oncogenic virus that has been strongly linked to various epithelial malignancies such as nasopharyng...

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Autores principales: Shechter, Oren, Sausen, Daniel G., Gallo, Elisa S., Dahari, Harel, Borenstein, Ronen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699474/
https://www.ncbi.nlm.nih.gov/pubmed/36430864
http://dx.doi.org/10.3390/ijms232214389
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author Shechter, Oren
Sausen, Daniel G.
Gallo, Elisa S.
Dahari, Harel
Borenstein, Ronen
author_facet Shechter, Oren
Sausen, Daniel G.
Gallo, Elisa S.
Dahari, Harel
Borenstein, Ronen
author_sort Shechter, Oren
collection PubMed
description Epstein–Barr virus (EBV) is one of eight known herpesviruses with the potential to infect humans. Globally, it is estimated that between 90–95% of the population has been infected with EBV. EBV is an oncogenic virus that has been strongly linked to various epithelial malignancies such as nasopharyngeal and gastric cancer. Recent evidence suggests a link between EBV and breast cancer. Additionally, there are other, rarer cancers with weaker evidence linking them to EBV. In this review, we discuss the currently known epithelial malignancies associated with EBV. Additionally, we discuss and establish which treatments and therapies are most recommended for each cancer associated with EBV.
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spelling pubmed-96994742022-11-26 Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments Shechter, Oren Sausen, Daniel G. Gallo, Elisa S. Dahari, Harel Borenstein, Ronen Int J Mol Sci Review Epstein–Barr virus (EBV) is one of eight known herpesviruses with the potential to infect humans. Globally, it is estimated that between 90–95% of the population has been infected with EBV. EBV is an oncogenic virus that has been strongly linked to various epithelial malignancies such as nasopharyngeal and gastric cancer. Recent evidence suggests a link between EBV and breast cancer. Additionally, there are other, rarer cancers with weaker evidence linking them to EBV. In this review, we discuss the currently known epithelial malignancies associated with EBV. Additionally, we discuss and establish which treatments and therapies are most recommended for each cancer associated with EBV. MDPI 2022-11-19 /pmc/articles/PMC9699474/ /pubmed/36430864 http://dx.doi.org/10.3390/ijms232214389 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shechter, Oren
Sausen, Daniel G.
Gallo, Elisa S.
Dahari, Harel
Borenstein, Ronen
Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments
title Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments
title_full Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments
title_fullStr Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments
title_full_unstemmed Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments
title_short Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments
title_sort epstein–barr virus (ebv) epithelial associated malignancies: exploring pathologies and current treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699474/
https://www.ncbi.nlm.nih.gov/pubmed/36430864
http://dx.doi.org/10.3390/ijms232214389
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