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Serological Survey of Mosquito-Borne Arboviruses in Wild Birds from Important Migratory Hotspots in Romania

In the context of climate change, globalization, and enhanced human traveling, arboviruses continue to represent a threat to public health. West Nile and Usutu viruses are mosquito-borne viruses belonging to the Flaviviridae family (Flavivirus genus) and members of the Japanese encephalitis virus se...

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Autores principales: Coroian, Mircea, Silaghi, Cornelia, Tews, Birke Andrea, Baltag, Emanuel Ștefan, Marinov, Mihai, Alexe, Vasile, Kalmár, Zsuzsa, Cintia, Horváth, Lupșe, Mihaela Sorina, Mihalca, Andrei Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699478/
https://www.ncbi.nlm.nih.gov/pubmed/36365021
http://dx.doi.org/10.3390/pathogens11111270
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author Coroian, Mircea
Silaghi, Cornelia
Tews, Birke Andrea
Baltag, Emanuel Ștefan
Marinov, Mihai
Alexe, Vasile
Kalmár, Zsuzsa
Cintia, Horváth
Lupșe, Mihaela Sorina
Mihalca, Andrei Daniel
author_facet Coroian, Mircea
Silaghi, Cornelia
Tews, Birke Andrea
Baltag, Emanuel Ștefan
Marinov, Mihai
Alexe, Vasile
Kalmár, Zsuzsa
Cintia, Horváth
Lupșe, Mihaela Sorina
Mihalca, Andrei Daniel
author_sort Coroian, Mircea
collection PubMed
description In the context of climate change, globalization, and enhanced human traveling, arboviruses continue to represent a threat to public health. West Nile and Usutu viruses are mosquito-borne viruses belonging to the Flaviviridae family (Flavivirus genus) and members of the Japanese encephalitis virus serocomplex. Included in the Togaviridae family (Alphavirus genus), the Sindbis virus is also vectored by mosquitoes. In the present study, we aimed to analyze the presence of antibodies concerning the abovementioned viruses in migratory and resident birds in the South-Eastern region of Romania, as avian hosts represent the main reservoir for human infection. Blood samples were collected from wild birds between May 2018 and October 2019 in nine locations from three counties. All the samples were serologically tested by ELISA and a serum neutralization test. Overall, a seroprevalence of 8.72% was registered for the West Nile virus, 2.71% for the Usutu virus, and 0% for the Sindbis virus. To our best knowledge, this is the first large-scale comprehensive study to assess the West Nile virus seropositivity in wild birds and the first serological confirmation of the Usutu virus in wild birds in Romania. Moreover, this is the only follow-up study reviewing the current seroprevalence of the Sindbis virus in Romania since 1975.
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spelling pubmed-96994782022-11-26 Serological Survey of Mosquito-Borne Arboviruses in Wild Birds from Important Migratory Hotspots in Romania Coroian, Mircea Silaghi, Cornelia Tews, Birke Andrea Baltag, Emanuel Ștefan Marinov, Mihai Alexe, Vasile Kalmár, Zsuzsa Cintia, Horváth Lupșe, Mihaela Sorina Mihalca, Andrei Daniel Pathogens Article In the context of climate change, globalization, and enhanced human traveling, arboviruses continue to represent a threat to public health. West Nile and Usutu viruses are mosquito-borne viruses belonging to the Flaviviridae family (Flavivirus genus) and members of the Japanese encephalitis virus serocomplex. Included in the Togaviridae family (Alphavirus genus), the Sindbis virus is also vectored by mosquitoes. In the present study, we aimed to analyze the presence of antibodies concerning the abovementioned viruses in migratory and resident birds in the South-Eastern region of Romania, as avian hosts represent the main reservoir for human infection. Blood samples were collected from wild birds between May 2018 and October 2019 in nine locations from three counties. All the samples were serologically tested by ELISA and a serum neutralization test. Overall, a seroprevalence of 8.72% was registered for the West Nile virus, 2.71% for the Usutu virus, and 0% for the Sindbis virus. To our best knowledge, this is the first large-scale comprehensive study to assess the West Nile virus seropositivity in wild birds and the first serological confirmation of the Usutu virus in wild birds in Romania. Moreover, this is the only follow-up study reviewing the current seroprevalence of the Sindbis virus in Romania since 1975. MDPI 2022-10-31 /pmc/articles/PMC9699478/ /pubmed/36365021 http://dx.doi.org/10.3390/pathogens11111270 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Coroian, Mircea
Silaghi, Cornelia
Tews, Birke Andrea
Baltag, Emanuel Ștefan
Marinov, Mihai
Alexe, Vasile
Kalmár, Zsuzsa
Cintia, Horváth
Lupșe, Mihaela Sorina
Mihalca, Andrei Daniel
Serological Survey of Mosquito-Borne Arboviruses in Wild Birds from Important Migratory Hotspots in Romania
title Serological Survey of Mosquito-Borne Arboviruses in Wild Birds from Important Migratory Hotspots in Romania
title_full Serological Survey of Mosquito-Borne Arboviruses in Wild Birds from Important Migratory Hotspots in Romania
title_fullStr Serological Survey of Mosquito-Borne Arboviruses in Wild Birds from Important Migratory Hotspots in Romania
title_full_unstemmed Serological Survey of Mosquito-Borne Arboviruses in Wild Birds from Important Migratory Hotspots in Romania
title_short Serological Survey of Mosquito-Borne Arboviruses in Wild Birds from Important Migratory Hotspots in Romania
title_sort serological survey of mosquito-borne arboviruses in wild birds from important migratory hotspots in romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699478/
https://www.ncbi.nlm.nih.gov/pubmed/36365021
http://dx.doi.org/10.3390/pathogens11111270
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