Host nucleases generate prespacers for primed adaptation in the E. coli type I-E CRISPR-Cas system

CRISPR-Cas systems provide prokaryotes with adaptive immunity against foreign nucleic acids. In Escherichia coli, immunity is acquired upon integration of 33-bp spacers into CRISPR arrays. DNA targets complementary to spacers get degraded and serve as a source of new spacers during a process called...

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Detalles Bibliográficos
Autores principales: Shiriaeva, Anna A., Kuznedelov, Konstantin, Fedorov, Ivan, Musharova, Olga, Khvostikov, Timofey, Tsoy, Yuliya, Kurilovich, Elena, Smith, Gerald R., Semenova, Ekaterina, Severinov, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699676/
https://www.ncbi.nlm.nih.gov/pubmed/36427302
http://dx.doi.org/10.1126/sciadv.abn8650

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