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Tolerogenic nanoparticles induce type II collagen–specific regulatory T cells and ameliorate osteoarthritis

Local inflammation in the joint is considered to contribute to osteoarthritis (OA) progression. Here, we describe an immunomodulating nanoparticle for OA treatment. Intradermal injection of lipid nanoparticles (LNPs) loaded with type II collagen (Col II) and rapamycin (LNP-Col II-R) into OA mice eff...

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Detalles Bibliográficos
Autores principales:	Sohn, Hee Su, Choi, Jeong Won, Jhun, JooYeon, Kwon, Sung Pil, Jung, Mungyo, Yong, Sangmin, Na, Hyun Sik, Kim, Jin-Hong, Cho, Mi-La, Kim, Byung-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699678/ https://www.ncbi.nlm.nih.gov/pubmed/36427299 http://dx.doi.org/10.1126/sciadv.abo5284

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