Cargando…
Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T cells
Exhausted CD8 T cells during chronic inflammatory responses against viral infections and cancer are phenotypically and functionally heterogeneous. In particular, CD8 T cells with cytolytic effector function have been recently identified among the exhausted CD8 T cell subsets. However, the regulation...
Autores principales: | Nah, Jinwoo, Seong, Rho H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699681/ https://www.ncbi.nlm.nih.gov/pubmed/36427304 http://dx.doi.org/10.1126/sciadv.adc9346 |
Ejemplares similares
-
Mitochondrial C1qbp promotes differentiation of effector CD8(+) T cells via metabolic-epigenetic reprogramming
por: Zhai, Xingyuan, et al.
Publicado: (2021) -
Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology
por: Hess, Nicholas J., et al.
Publicado: (2023) -
SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8(+) T cell cytotoxic function
por: Liu, Xinwei, et al.
Publicado: (2022) -
Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR
por: Manfredi, Francesco, et al.
Publicado: (2023) -
Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8(+) T cells via ME1 up-regulation
por: Gicobi, Joanina K., et al.
Publicado: (2023)