Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing

As the most common cause of heart failure, dilated cardiomyopathy (DCM) is characterized by dilated ventricles and weakened contractile force. Mutations in the calcium handling protein phospholamban (PLN) are known to cause inherited DCM. Here, we introduced a PLN-R9C mutation in a healthy control i...

Descripción completa

Detalles Bibliográficos
Autores principales: Barndt, Robert J., Ma, Ning, Tang, Ying, Haugh, Michael P., Alamri, Laila S., Chan, Stephen Y., Wu, Haodi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699793/
https://www.ncbi.nlm.nih.gov/pubmed/34583280
http://dx.doi.org/10.1016/j.scr.2021.102544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699793/
https://www.ncbi.nlm.nih.gov/pubmed/34583280
http://dx.doi.org/10.1016/j.scr.2021.102544

Ejemplares similares