Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity

Nucleic acid-binding polymers can have anti-inflammatory properties and beneficial effects in animal models of infection, trauma, cancer, and autoimmunity. PAMAM G3, a polyamidoamine dendrimer, is fully cationic bearing 32 protonable surface amines. However, while PAMAM G3 treatment leads to improve...

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Detalles Bibliográficos
Autores principales: Olson, Lyra B., Hunter, Nicole I., Rempel, Rachel E., Yu, Haixiang, Spencer, Diane M., Sullenger, Cynthia Z., Greene, William S., Varanko, Anastasia K., Eghtesadi, Seyed A., Chilkoti, Ashutosh, Pisetsky, David S., Everitt, Jeffrey I., Sullenger, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700028/
https://www.ncbi.nlm.nih.gov/pubmed/36444294
http://dx.doi.org/10.1016/j.isci.2022.105542

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