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Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events
Cervical spondylotic myelopathy is the main cause of non-traumatic spinal cord injury, with chronic static and/or dynamic compressive spinal cord injury as the unique pathogenesis. In the progression of this condition, the microvascular network is compressed and destroyed, resulting in ischemia and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700100/ https://www.ncbi.nlm.nih.gov/pubmed/36204839 http://dx.doi.org/10.4103/1673-5374.353485 |
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author | Ren, Zhen-Xiao Xu, Jing-Hui Cheng, Xing Xu, Gui-Xing Long, Hou-Qing |
author_facet | Ren, Zhen-Xiao Xu, Jing-Hui Cheng, Xing Xu, Gui-Xing Long, Hou-Qing |
author_sort | Ren, Zhen-Xiao |
collection | PubMed |
description | Cervical spondylotic myelopathy is the main cause of non-traumatic spinal cord injury, with chronic static and/or dynamic compressive spinal cord injury as the unique pathogenesis. In the progression of this condition, the microvascular network is compressed and destroyed, resulting in ischemia and hypoxia. The main pathological changes are inflammation, damage to the blood spinal cord barriers, and cell apoptosis at the site of compression. Studies have confirmed that vascular regeneration and remodeling contribute to neural repair by promoting blood flow and the reconstruction of effective circulation to meet the nutrient and oxygen requirements for nerve repair. Surgical decompression is the most effective clinical treatment for this condition; however, in some patients, residual neurological dysfunction remains after decompression. Facilitating revascularization during compression and after decompression is therefore complementary to surgical treatment. In this review, we summarize the progress in research on chronic compressive spinal cord injury, covering both physiological and pathological changes after compression and decompression, and the regulatory mechanisms of vascular injury and repair. |
format | Online Article Text |
id | pubmed-9700100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-97001002022-11-27 Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events Ren, Zhen-Xiao Xu, Jing-Hui Cheng, Xing Xu, Gui-Xing Long, Hou-Qing Neural Regen Res Review Cervical spondylotic myelopathy is the main cause of non-traumatic spinal cord injury, with chronic static and/or dynamic compressive spinal cord injury as the unique pathogenesis. In the progression of this condition, the microvascular network is compressed and destroyed, resulting in ischemia and hypoxia. The main pathological changes are inflammation, damage to the blood spinal cord barriers, and cell apoptosis at the site of compression. Studies have confirmed that vascular regeneration and remodeling contribute to neural repair by promoting blood flow and the reconstruction of effective circulation to meet the nutrient and oxygen requirements for nerve repair. Surgical decompression is the most effective clinical treatment for this condition; however, in some patients, residual neurological dysfunction remains after decompression. Facilitating revascularization during compression and after decompression is therefore complementary to surgical treatment. In this review, we summarize the progress in research on chronic compressive spinal cord injury, covering both physiological and pathological changes after compression and decompression, and the regulatory mechanisms of vascular injury and repair. Wolters Kluwer - Medknow 2022-09-16 /pmc/articles/PMC9700100/ /pubmed/36204839 http://dx.doi.org/10.4103/1673-5374.353485 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Ren, Zhen-Xiao Xu, Jing-Hui Cheng, Xing Xu, Gui-Xing Long, Hou-Qing Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events |
title | Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events |
title_full | Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events |
title_fullStr | Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events |
title_full_unstemmed | Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events |
title_short | Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events |
title_sort | pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700100/ https://www.ncbi.nlm.nih.gov/pubmed/36204839 http://dx.doi.org/10.4103/1673-5374.353485 |
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