Cargando…

Safety and immunogenicity of AGS-v PLUS, a mosquito saliva peptide vaccine against arboviral diseases: A randomized, double-blind, placebo-controlled Phase 1 trial

BACKGROUND: Immunity to mosquito salivary proteins could provide protection against multiple mosquito-borne diseases and significantly impact public health. We evaluated the safety and immunogenicity of AGS-v PLUS, a mosquito salivary peptide vaccine, in healthy adults 18–50 years old. METHODS: We c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Friedman-Klabanoff, DeAnna J., Birkhold, Megan, Short, Mara T., Wilson, Timothy R., Meneses, Claudio R., Lacsina, Joshua R., Oliveira, Fabiano, Kamhawi, Shaden, Valenzuela, Jesus G., Hunsberger, Sally, Mateja, Allyson, Stoloff, Gregory, Pleguezuelos, Olga, Memoli, Matthew J., Laurens, Matthew B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700263/ https://www.ncbi.nlm.nih.gov/pubmed/36436281 http://dx.doi.org/10.1016/j.ebiom.2022.104375

Ejemplares similares

The PAGODAS protocol: pediatric assessment group of dengue and Aedes saliva protocol to investigate vector-borne determinants of Aedes-transmitted arboviral infections in Cambodia
por: Manning, Jessica E., et al.
Publicado: (2018)

Vector Saliva in Vaccines for Visceral Leishmaniasis: A Brief Encounter of High Consequence?
por: Kamhawi, Shaden, et al.
Publicado: (2014)

Saliva collection via capillary method may underestimate arboviral transmission by mosquitoes
por: Gloria-Soria, A., et al.
Publicado: (2022)

Immunity to vector saliva is compromised by short sand fly seasons in endemic regions with temperate climates
por: Oliveira, Fabiano, et al.
Publicado: (2020)

Sequential blood meals augment vector infectiousness by promoting Leishmania replication and triggering amplification of metacyclics via a novel retroleptomonad developmental stage
por: Serafim, Tiago D., et al.
Publicado: (2018)

Leishmania infection induces a limited differential gene expression in the sand fly midgut
por: Coutinho-Abreu, Iliano V., et al.
Publicado: (2020)

Distinct gene expression patterns in vector-residing Leishmania infantum identify parasite stage-enriched markers
por: Coutinho-Abreu, Iliano V., et al.
Publicado: (2020)

Development of a Natural Model of Cutaneous Leishmaniasis: Powerful Effects of Vector Saliva and Saliva Preexposure on the Long-Term Outcome of Leishmania major Infection in the Mouse Ear Dermis
por: Belkaid, Yasmine, et al.
Publicado: (1998)

Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study
por: Pleguezuelos, Olga, et al.
Publicado: (2020)

Immunity to Distinct Sand Fly Salivary Proteins Primes the Anti-Leishmania Immune Response towards Protection or Exacerbation of Disease
por: Oliveira, Fabiano, et al.
Publicado: (2008)

Immunity to Sand Fly Salivary Protein LJM11 Modulates Host Response to Vector-Transmitted Leishmania Conferring Ulcer-Free Protection
por: Gomes, Regis, et al.
Publicado: (2012)

Characterization of the Early Inflammatory Infiltrate at the Feeding Site of Infected Sand Flies in Mice Protected from Vector-Transmitted Leishmania major by Exposure to Uninfected Bites
por: Teixeira, Clarissa, et al.
Publicado: (2014)

Antiviral Compounds for Blocking Arboviral Transmission in Mosquitoes
por: Dong, Shengzhang, et al.
Publicado: (2021)

Delayed-Type Hypersensitivity to Sand Fly Saliva in Humans from a Leishmaniasis-Endemic Area of Mali Is T(H)1-Mediated and Persists to Midlife
por: Oliveira, Fabiano, et al.
Publicado: (2013)

Synthetic immunotherapy induces HIV virus specific Th1 cytotoxic response and death of an HIV-1 infected human cell line through classic complement activation
por: Pleguezuelos, Olga, et al.
Publicado: (2013)

Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable Protective Immune Response in Hamsters
por: Fiuza, Jacqueline Araújo, et al.
Publicado: (2016)

Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis
por: Pereira, Lais, et al.
Publicado: (2018)

SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis
por: Ferreira, Viviana P., et al.
Publicado: (2016)

Urban Ecology of Arboviral Mosquito Vectors Along the Kenyan Coast
por: Karisa, Jonathan, et al.
Publicado: (2021)

Arboviral diseases in pediatrics()()
por: Martins, Marlos Melo, et al.
Publicado: (2019)

Building Research and Development Capacity for Neglected Tropical Diseases Impacting Leishmaniasis in the Middle East and North Africa: A Case Study
por: Rafati, Sima, et al.
Publicado: (2015)

FLU-v, a Broad-Spectrum Influenza Vaccine, Induces Cross-Reactive Cellular Immune Responses in Humans Measured by Dual IFN-γ and Granzyme B ELISpot Assay
por: Oftung, Fredrik, et al.
Publicado: (2022)

Individuals co-exposed to sand fly saliva and filarial parasites exhibit altered monocyte function
por: Sangare, Moussa, et al.
Publicado: (2021)

Arboviral Bottlenecks and Challenges to Maintaining Diversity and Fitness during Mosquito Transmission
por: Forrester, Naomi L., et al.
Publicado: (2014)

Virus-derived DNA drives mosquito vector tolerance to arboviral infection
por: Goic, Bertsy, et al.
Publicado: (2016)

Commensal Viruses of Mosquitoes: Host Restriction, Transmission, and Interaction with Arboviral Pathogens
por: Hall, Roy A., et al.
Publicado: (2017)

Entomological Assessment of the Status and Risk of Mosquito-borne Arboviral Transmission in Ghana
por: Amoa-Bosompem, Michael, et al.
Publicado: (2020)

Population bottlenecks and founder effects: implications for mosquito-borne arboviral emergence
por: Weaver, Scott C., et al.
Publicado: (2021)

Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
por: Luz, Nivea F., et al.
Publicado: (2018)

The yin and yang of leishmaniasis control
por: Kamhawi, Shaden
Publicado: (2017)

Patterns of mosquito and arbovirus community composition and ecological indexes of arboviral risk in the northeast United States
por: McMillan, Joseph R., et al.
Publicado: (2020)

Increasing Public Health Mosquito Surveillance in Hidalgo County, Texas to Monitor Vector and Arboviral Presence
por: Guerrero, Clarissa D., et al.
Publicado: (2021)

Evolutionary Influences in Arboviral Disease
por: Weaver, S. C.
Publicado: (2006)

New Insights Into the Transmissibility of Leishmania infantum From Dogs to Sand Flies: Experimental Vector-Transmission Reveals Persistent Parasite Depots at Bite Sites
por: Aslan, Hamide, et al.
Publicado: (2016)

KSAC, a Defined Leishmania Antigen, plus Adjuvant Protects against the Virulence of L. major Transmitted by Its Natural Vector Phlebotomus duboscqi
por: Gomes, Regis, et al.
Publicado: (2012)

El Niño and arboviral disease prediction.
por: Maelzer, D, et al.
Publicado: (1999)

The Neglected Arboviral Infections in Mainland China
por: Gao, Xiaoyan, et al.
Publicado: (2010)

The Endless Challenges of Arboviral Diseases in Brazil
por: Magalhaes, Tereza, et al.
Publicado: (2020)

Nervous System Manifestations of Arboviral Infections
por: Chauhan, Lakshmi, et al.
Publicado: (2022)

The potential role of Wolbachia in controlling the transmission of emerging human arboviral infections
por: Kamtchum-Tatuene, Joseph, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_90tlu9tp8m6549eb4g8quqirpj