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An arrayed CRISPR screen reveals Myc depletion to increase productivity of difficult-to-express complex antibodies in CHO cells

Complex therapeutic antibody formats, such as bispecifics (bsAbs) or cytokine fusions, may provide new treatment options in diverse disease areas. However, the manufacturing yield of these complex antibody formats in Chinese Hamster Ovary (CHO) cells is lower than monoclonal antibodies due to challe...

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Detalles Bibliográficos
Autores principales:	Bauer, Niels, Oswald, Benedikt, Eiche, Maximilian, Schiller, Lisa, Langguth, Emma, Schantz, Christian, Osterlehner, Andrea, Shen, Amy, Misaghi, Shahram, Stingele, Julian, Ausländer, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700384/ https://www.ncbi.nlm.nih.gov/pubmed/36452067 http://dx.doi.org/10.1093/synbio/ysac026

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