A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation

N-glycan-mediated activation of the thrombopoietin receptor (MPL) under pathological conditions has been implicated in myeloproliferative neoplasms induced by mutant calreticulin, which forms an endogenous receptor-agonist complex that traffics to the cell surface and constitutively activates the re...

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Detalles Bibliográficos
Autores principales: Watari, Hiromi, Kageyama, Hiromu, Masubuchi, Nami, Nakajima, Hiroya, Onodera, Kako, Focia, Pamela J., Oshiro, Takumi, Matsui, Takashi, Kodera, Yoshio, Ogawa, Tomohisa, Yokoyama, Takeshi, Hirayama, Makoto, Hori, Kanji, Freymann, Douglas M., Imai, Misa, Komatsu, Norio, Araki, Marito, Tanaka, Yoshikazu, Sakai, Ryuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700728/
https://www.ncbi.nlm.nih.gov/pubmed/36433967
http://dx.doi.org/10.1038/s41467-022-34921-2

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