Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning

Pesticides account for hundreds of millions of cases of acute poisoning worldwide each year, with organophosphates (OPs) being responsible for the majority of all pesticide-related deaths. OPs inhibit the enzyme acetylcholinesterase (AChE), which leads to impairment of the central- and peripheral ne...

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Detalles Bibliográficos
Autores principales: Piel, Sarah, Janowska, Joanna I., Ward, J. Laurenson, McManus, Meagan J., Jose, Joshua S., Starr, Jonathan, Sheldon, Malkah, Clayman, Carly L., Elmér, Eskil, Hansson, Magnus J., Jang, David H., Karlsson, Michael, Ehinger, Johannes K., Kilbaugh, Todd J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700731/
https://www.ncbi.nlm.nih.gov/pubmed/36434021
http://dx.doi.org/10.1038/s41598-022-24472-3

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