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Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia

Skeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial energy production during exercise is impaired in vitamin D-deficient subjects. In cultured myotubes, loss of vitamin D receptor (VDR) function decreases mitochondrial respiration rate and ATP p...

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Autores principales: Salles, Jérôme, Chanet, Audrey, Guillet, Christelle, Vaes, Anouk MM., Brouwer-Brolsma, Elske M., Rocher, Christophe, Giraudet, Christophe, Patrac, Véronique, Meugnier, Emmanuelle, Montaurier, Christophe, Denis, Philippe, Le Bacquer, Olivier, Blot, Adeline, Jourdan, Marion, Luiking, Yvette, Furber, Matthew, Van Dijk, Miriam, Tardif, Nicolas, Yves Boirie, Y., Walrand, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700804/
https://www.ncbi.nlm.nih.gov/pubmed/36434267
http://dx.doi.org/10.1038/s42003-022-04246-3
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author Salles, Jérôme
Chanet, Audrey
Guillet, Christelle
Vaes, Anouk MM.
Brouwer-Brolsma, Elske M.
Rocher, Christophe
Giraudet, Christophe
Patrac, Véronique
Meugnier, Emmanuelle
Montaurier, Christophe
Denis, Philippe
Le Bacquer, Olivier
Blot, Adeline
Jourdan, Marion
Luiking, Yvette
Furber, Matthew
Van Dijk, Miriam
Tardif, Nicolas
Yves Boirie, Y.
Walrand, Stéphane
author_facet Salles, Jérôme
Chanet, Audrey
Guillet, Christelle
Vaes, Anouk MM.
Brouwer-Brolsma, Elske M.
Rocher, Christophe
Giraudet, Christophe
Patrac, Véronique
Meugnier, Emmanuelle
Montaurier, Christophe
Denis, Philippe
Le Bacquer, Olivier
Blot, Adeline
Jourdan, Marion
Luiking, Yvette
Furber, Matthew
Van Dijk, Miriam
Tardif, Nicolas
Yves Boirie, Y.
Walrand, Stéphane
author_sort Salles, Jérôme
collection PubMed
description Skeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial energy production during exercise is impaired in vitamin D-deficient subjects. In cultured myotubes, loss of vitamin D receptor (VDR) function decreases mitochondrial respiration rate and ATP production from oxidative phosphorylation. We aimed to examine the effects of vitamin D deficiency and supplementation on whole-body energy expenditure and muscle mitochondrial function in old rats, old mice, and human subjects. To gain further insight into the mechanisms involved, we used C2C12 and human muscle cells and transgenic mice with muscle-specific VDR tamoxifen-inducible deficiency. We observed that in vivo and in vitro vitamin D fluctuations changed mitochondrial biogenesis and oxidative activity in skeletal muscle. Vitamin D supplementation initiated in older people improved muscle mass and strength. We hypothesize that vitamin D supplementation is likely to help prevent not only sarcopenia but also sarcopenic obesity in vitamin D-deficient subjects.
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spelling pubmed-97008042022-11-27 Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia Salles, Jérôme Chanet, Audrey Guillet, Christelle Vaes, Anouk MM. Brouwer-Brolsma, Elske M. Rocher, Christophe Giraudet, Christophe Patrac, Véronique Meugnier, Emmanuelle Montaurier, Christophe Denis, Philippe Le Bacquer, Olivier Blot, Adeline Jourdan, Marion Luiking, Yvette Furber, Matthew Van Dijk, Miriam Tardif, Nicolas Yves Boirie, Y. Walrand, Stéphane Commun Biol Article Skeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial energy production during exercise is impaired in vitamin D-deficient subjects. In cultured myotubes, loss of vitamin D receptor (VDR) function decreases mitochondrial respiration rate and ATP production from oxidative phosphorylation. We aimed to examine the effects of vitamin D deficiency and supplementation on whole-body energy expenditure and muscle mitochondrial function in old rats, old mice, and human subjects. To gain further insight into the mechanisms involved, we used C2C12 and human muscle cells and transgenic mice with muscle-specific VDR tamoxifen-inducible deficiency. We observed that in vivo and in vitro vitamin D fluctuations changed mitochondrial biogenesis and oxidative activity in skeletal muscle. Vitamin D supplementation initiated in older people improved muscle mass and strength. We hypothesize that vitamin D supplementation is likely to help prevent not only sarcopenia but also sarcopenic obesity in vitamin D-deficient subjects. Nature Publishing Group UK 2022-11-24 /pmc/articles/PMC9700804/ /pubmed/36434267 http://dx.doi.org/10.1038/s42003-022-04246-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Salles, Jérôme
Chanet, Audrey
Guillet, Christelle
Vaes, Anouk MM.
Brouwer-Brolsma, Elske M.
Rocher, Christophe
Giraudet, Christophe
Patrac, Véronique
Meugnier, Emmanuelle
Montaurier, Christophe
Denis, Philippe
Le Bacquer, Olivier
Blot, Adeline
Jourdan, Marion
Luiking, Yvette
Furber, Matthew
Van Dijk, Miriam
Tardif, Nicolas
Yves Boirie, Y.
Walrand, Stéphane
Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
title Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
title_full Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
title_fullStr Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
title_full_unstemmed Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
title_short Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
title_sort vitamin d status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700804/
https://www.ncbi.nlm.nih.gov/pubmed/36434267
http://dx.doi.org/10.1038/s42003-022-04246-3
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