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Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome

In mammalian cells, SET8 mediated Histone H4 Lys 20 monomethylation (H4K20me1) has been implicated in regulating mitotic condensation, DNA replication, DNA damage response, and gene expression. Here we show SET8, the only known enzyme for H4K20me1 is post-translationally poly ADP-ribosylated by PARP...

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Detalles Bibliográficos
Autores principales:	Estève, Pierre-Olivier, Sen, Sagnik, Vishnu, Udayakumar S., Ruse, Cristian, Chin, Hang Gyeong, Pradhan, Sriharsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700808/ https://www.ncbi.nlm.nih.gov/pubmed/36434141 http://dx.doi.org/10.1038/s42003-022-04241-8

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