AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis

Tumour cell metabolic plasticity is essential for tumour progression and therapeutic responses, yet the underlying mechanisms remain poorly understood. Here, we identify Prospero-related homeobox 1 (PROX1) as a crucial factor for tumour metabolic plasticity. Notably, PROX1 is reduced by glucose star...

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Detalles Bibliográficos
Autores principales: Wang, Yanan, Luo, Mengjun, Wang, Fan, Tong, Yu, Li, Linfeng, Shu, Yu, Qiao, Ke, Zhang, Lei, Yan, Guoquan, Liu, Jing, Ji, Hongbin, Xie, Youhua, Zhang, Yonglong, Gao, Wei-Qiang, Liu, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700865/
https://www.ncbi.nlm.nih.gov/pubmed/36433955
http://dx.doi.org/10.1038/s41467-022-34747-y

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