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Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders

Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G protein-dependent regulation of Cav2.2 (N-type) voltage-gated calcium channels (VGCCs). This typically causes a reduction in calcium currents, triggering cha...

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Autores principales: Caminski, Emanuelle Sistherenn, Antunes, Flavia Tasmin Techera, Souza, Ivana Assis, Dallegrave, Eliane, Zamponi, Gerald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700961/
https://www.ncbi.nlm.nih.gov/pubmed/36434658
http://dx.doi.org/10.1186/s13041-022-00982-z
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author Caminski, Emanuelle Sistherenn
Antunes, Flavia Tasmin Techera
Souza, Ivana Assis
Dallegrave, Eliane
Zamponi, Gerald W.
author_facet Caminski, Emanuelle Sistherenn
Antunes, Flavia Tasmin Techera
Souza, Ivana Assis
Dallegrave, Eliane
Zamponi, Gerald W.
author_sort Caminski, Emanuelle Sistherenn
collection PubMed
description Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G protein-dependent regulation of Cav2.2 (N-type) voltage-gated calcium channels (VGCCs). This typically causes a reduction in calcium currents, triggering changes in presynaptic calcium levels and thus neurotransmission. Because of the widespread expression patterns of NOP and VGCCs across multiple brain regions, the dorsal horn of the spinal cord, and the dorsal root ganglia, this results in the alteration of numerous neurophysiological features. Here we review the regulation of N-type calcium channels by the NOP-nociceptin system in the context of neurological conditions such as anxiety, addiction, and pain.
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spelling pubmed-97009612022-11-27 Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders Caminski, Emanuelle Sistherenn Antunes, Flavia Tasmin Techera Souza, Ivana Assis Dallegrave, Eliane Zamponi, Gerald W. Mol Brain Review Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G protein-dependent regulation of Cav2.2 (N-type) voltage-gated calcium channels (VGCCs). This typically causes a reduction in calcium currents, triggering changes in presynaptic calcium levels and thus neurotransmission. Because of the widespread expression patterns of NOP and VGCCs across multiple brain regions, the dorsal horn of the spinal cord, and the dorsal root ganglia, this results in the alteration of numerous neurophysiological features. Here we review the regulation of N-type calcium channels by the NOP-nociceptin system in the context of neurological conditions such as anxiety, addiction, and pain. BioMed Central 2022-11-24 /pmc/articles/PMC9700961/ /pubmed/36434658 http://dx.doi.org/10.1186/s13041-022-00982-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Caminski, Emanuelle Sistherenn
Antunes, Flavia Tasmin Techera
Souza, Ivana Assis
Dallegrave, Eliane
Zamponi, Gerald W.
Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
title Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
title_full Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
title_fullStr Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
title_full_unstemmed Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
title_short Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders
title_sort regulation of n-type calcium channels by nociceptin receptors and its possible role in neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700961/
https://www.ncbi.nlm.nih.gov/pubmed/36434658
http://dx.doi.org/10.1186/s13041-022-00982-z
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