Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders

Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G protein-dependent regulation of Cav2.2 (N-type) voltage-gated calcium channels (VGCCs). This typically causes a reduction in calcium currents, triggering cha...

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Detalles Bibliográficos
Autores principales: Caminski, Emanuelle Sistherenn, Antunes, Flavia Tasmin Techera, Souza, Ivana Assis, Dallegrave, Eliane, Zamponi, Gerald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700961/
https://www.ncbi.nlm.nih.gov/pubmed/36434658
http://dx.doi.org/10.1186/s13041-022-00982-z

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